Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials.

Autor: Lőrincz A; Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary., Váradi A; Department of Biostatistics, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary., Hegyi P; Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, Hungary.; Centre for Translational Medicine, Semmelweis University, 26 Üllői Street, H1085 Budapest, Hungary.; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, H1124 Budapest, Hungary., Rumbus Z; Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary., Tuba M; Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary., Lamberti AG; Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary.; Division of Surgery, Traumatology and Otorhinolaryngology, Department of Paediatrics, Clinical Complex, University of Pécs, 7 József Attila Street, H7623 Pécs, Hungary., Varjú-Solymár M; Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, Hungary., Párniczky A; Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, Hungary., Erőss B; Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 20 Ifjúság Street, H7624 Pécs, Hungary.; Centre for Translational Medicine, Semmelweis University, 26 Üllői Street, H1085 Budapest, Hungary.; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, H1124 Budapest, Hungary., Garami A; Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary., Józsa G; Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary.; Division of Surgery, Traumatology and Otorhinolaryngology, Department of Paediatrics, Clinical Complex, University of Pécs, 7 József Attila Street, H7623 Pécs, Hungary.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2022 Apr 21; Vol. 12 (5). Date of Electronic Publication: 2022 Apr 21.
DOI: 10.3390/life12050619
Abstrakt: Background: Paediatric second-degree burn injuries are a significant source of medical challenges to the population that may cause severe, lifelong complications. Currently, there are dozens of therapeutic modalities and we aimed to summarise their reported outcomes and determine their effectiveness, compared to the widely used silver sulphadiazine (SSD).
Methods: We conducted the meta-analysis and systematic review of randomised controlled trials (RCTs), which investigated the performance of dressings in acute paediatric partial-thickness burns. The evaluated endpoints were time until wound closure, grafting and infection rate, number of dressing changes and length of hospitalisation.
Results: Twenty-nine RCTs were included in the qualitative and 25 in the quantitative synthesis, but only three trials compared SSD directly to the same intervention (Biobrane). Data analysis showed a tendency for faster healing times and a reduced complication rate linked to biosynthetic, silver foam and amnion membrane dressings. A substantial difference was found between the number of dressing changes associated with less pain, narcosis and treatment duration.
Conclusions: Considerable between-study heterogeneity was caused by the unequal depth subcategory ratio and surface area of the injuries; therefore, no significant difference was found in the main outcomes. Further research is necessary to establish the most effective treatment for these burns.
Databáze: MEDLINE
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