| Autor: |
Citu C; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania., Burlea B; Department of Obstetrics and Gynecology, Municipal Emergency Clinical Hospital Timisoara, 1-3 Alexandru Odobescu Street, 300202 Timisoara, Romania., Gorun F; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania., Motoc A; Department of Anatomy and Embryology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania., Gorun OM; Department of Obstetrics and Gynecology, Municipal Emergency Clinical Hospital Timisoara, 1-3 Alexandru Odobescu Street, 300202 Timisoara, Romania., Malita D; Department of Radiology, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania., Ratiu A; Department of Obstetrics and Gynecology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania., Margan R; Department 14 Microbiology, Discipline of Hygiene, Center for Studies in Preventive Medicine, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Grigoras ML; Department of Anatomy and Embryology, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania., Bratosin F; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania., Citu IM; Department of Internal Medicine I, 'Victor Babes' University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania. |
| Abstrakt: |
SARS-CoV-2 infection produces alterations in blood clotting, especially in severe cases of COVID-19. Abnormal coagulation parameters in patients with COVID-19 are important prognostic factors of disease severity. The objective of this study was to evaluate the predictive value of aPTT, D-dimer, INR and PT in the mortality of patients with COVID-19. A retrospective, single-center, observational study was conducted on COVID-19 patients admitted to the Municipal Emergency Clinical Hospital in Timisoara, Romania, between August and October 2021. Patients were confirmed as COVID-19 positive by reverse transcription-polymerase chain reaction (RT-PCR) assay. After applying the inclusion/exclusion criteria, a total of 82 patients were included in the analysis. Receiver operating characteristic (ROC) curves of D-Dimer, INR, PT and aPTT were generated to assess whether the baseline of each of these biomarkers was accurately predictive for mortality in patients with COVID-19. Mortality among patients enrolled in this study was 20.7%, associated with older age and presence of heart disease. The areas under the ROC curve (AUC-ROC) of D-Dimer, INR, PT, and aPTT were 0.751, 0.724, 0.706 and 0.753. Differences in survival for patients with coagulation biomarker levels above cut-off values compared to patients below these values were statistically significant. All evaluated parameters had significant differences and good performance in predicting mortality of COVID-19 patients, except fibrinogen, which had no significant difference. Moreover, aPTT and D-dimer were the best performing parameters in predicting mortality in patients with SARS-CoV-2 infection. |
