| Autor: |
Pagani S; Department of Medicine, ASST Vimercate, 20871 Vimercate, Italy., Lombardi N; Section of Pharmacology and Toxicology, Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.; Tuscan Regional Centre of Pharmacovigilance, 50122 Florence, Italy., Crescioli G; Section of Pharmacology and Toxicology, Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.; Tuscan Regional Centre of Pharmacovigilance, 50122 Florence, Italy., Vighi VG; Hospital Pharmacy, ASST Vimercate, 20871 Vimercate, Italy., Spada G; Hospital Pharmacy, ASST Vimercate, 20871 Vimercate, Italy., Andreetta P; Department of Medicine, ASST Vimercate, 20871 Vimercate, Italy., Capuano A; Section of Pharmacology 'L. Donatelli', Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.; Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, Italy., Vannacci A; Section of Pharmacology and Toxicology, Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.; Tuscan Regional Centre of Pharmacovigilance, 50122 Florence, Italy., Venegoni M; Department of Medicine, ASST Vimercate, 20871 Vimercate, Italy.; Pharmacology Unit, Department of Diagnostics and Public Health, University of Verona, 37100 Verona, Italy., Vighi GD; Department of Medicine, ASST Vimercate, 20871 Vimercate, Italy., On Behalf Of The MEREAFaPS Study Group |
| Abstrakt: |
The aim of the present study is to describe pharmacological characteristics of drug-related allergies and anaphylaxis leading to the emergency department (ED). An 8-year post hoc analysis on the MEREAFaPS Study database was performed (2012−2019). Subjects who experienced drug-related hypersensitivity leading to an ED visit were selected. Logistic regression analyses were used to estimate the reporting odds ratios (RORs) of drug-related allergies and anaphylaxis adjusting for sex, age classes, and ethnicity. In addition, a systematic review of observational studies evaluating drug-related hypersensitivity reactions leading to ED visits in outpatients was performed. Out of 94,073 ED visits, 14.4% cases were drug-related allergies and 0.6% were anaphylaxis. Females accounted for 56%. Multivariate logistic regression showed a higher risk of drug-related allergy among males and all age classes < 65 years, while a higher risk of anaphylaxis was observed for females (ROR 1.20 [1.01−1.42]) and adults (ROR 2.63 [2.21−3.14]). The systematic review included 37 studies. ED visits related to allergy and anaphylaxis ranged from 0.004% to 88%, and drug-related allergies and anaphylaxis ranged from 0.007% to 88%. Both in our analysis and in primary studies, antibacterials, analgesics, and radiocontrast agents were identified as the most common triggers of hypersensitivity. |
