The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis.

Autor:	Plotogea OM; Department 5, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Diaconu CC; Department 5, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Internal Medicine, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Gheorghe G; Department 5, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Stan-Ilie M; Department 5, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Oprita R; Department 5, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Sandru V; Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Bacalbasa N; Department of Visceral Surgery, Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 'Carol Davila' University of Medicine and Pharmacy, 022328 Bucharest, Romania., Constantinescu G; Department 5, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2022 Apr 28; Vol. 10 (5). Date of Electronic Publication: 2022 Apr 28.
DOI:	10.3390/healthcare10050822
Abstrakt:	Introduction and Aim: Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of patients with liver cirrhosis. Material and Methods: We performed a cross-sectional prospective study over a period of 14 months and enrolled 69 patients with liver cirrhosis, after applying the inclusion and exclusion criteria. The cases of RLS were assessed according to the International Restless Legs Syndrome Study Group (IRLSSG) criteria and severity scale. Results: Out of the total number of patients, 55% fulfilled the criteria for RLS. Age, diabetes, severity of cirrhosis, serum creatinine, glomerular filtration rate (GFR), and mean hemoglobin were associated with the presence of RLS. Moreover, there was a significantly higher prevalence of RLS among patients with decompensated cirrhosis. From all the risk factors introduced into the multivariate analysis, only the GFR could predict the presence of RLS. Conclusions: This research shows that patients with liver cirrhosis have a high risk of RLS. Even though there are multiple risk factors associated with RLS, only the GFR could predict its occurrence in our cohort.
Databáze:	MEDLINE
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