Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health.

Autor: Willemars MMA; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands., Nabben M; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands., Verdonschot JAJ; CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands., Hoes MF; CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands. martijn.hoes@maastrichtuniversity.nl.; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands. martijn.hoes@maastrichtuniversity.nl.; Department of Cardiology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands. martijn.hoes@maastrichtuniversity.nl.
Jazyk: angličtina
Zdroj: Current heart failure reports [Curr Heart Fail Rep] 2022 Aug; Vol. 19 (4), pp. 200-212. Date of Electronic Publication: 2022 May 28.
DOI: 10.1007/s11897-022-00555-0
Abstrakt: Purpose of Review: Sex hormones drive development and function of reproductive organs or the development of secondary sex characteristics but their effects on the cardiovascular system are poorly understood. In this review, we identify the gaps in our understanding of the interaction between sex hormones and the cardiovascular system.
Recent Findings: Studies are progressively elucidating molecular functions of sex hormones in specific cell types in parallel with the initiation of crucial large randomized controlled trials aimed at improving therapies for cardiovascular diseases (CVDs) associated with aberrant levels of sex hormones. In contrast with historical assumptions, we now understand that men and women show different symptoms and progression of CVDs. Abnormal levels of sex hormones pose an independent risk for CVD, which is apparent in conditions like Klinefelter syndrome, androgen insensitivity syndrome, and menopause. Moreover, sex hormone-based therapies remain understudied and may not be beneficial for cardiovascular health.
(© 2022. The Author(s).)
Databáze: MEDLINE
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