Therapeutic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers.

Autor: Pham Thi HH; NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City, 700000, Vietnam., Phan Thi TV; Department of Animal Nutrition and Feedstuffs, Institute of Animal Sciences for Southern Vietnam, Hiep Thang, Binh Thang, Di An, Binh Duong, VietNam., Pham Huynh N; Department of Animal Nutrition and Feedstuffs, Institute of Animal Sciences for Southern Vietnam, Hiep Thang, Binh Thang, Di An, Binh Duong, VietNam., Doan V; Department of Animal Nutrition and Feedstuffs, Institute of Animal Sciences for Southern Vietnam, Hiep Thang, Binh Thang, Di An, Binh Duong, VietNam., Onoda S; House Wellness Foods company, Japan., Nguyen TL; Department of Technology, Science and International Affair, HUTECH University, 475A Dien Bien Phu Street, Ward 25, Binh Thanh District, Ho Chi Minh City, 700000, Vietnam. Electronic address: nt.luan@hutech.edu.vn.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2022 Aug; Vol. 232, pp. 106537. Date of Electronic Publication: 2022 May 24.
DOI: 10.1016/j.actatropica.2022.106537
Abstrakt: Although some studies on the effects of para-probiotics on the immune system and intestinal health have been conducted independently of research on antibiotics ass growth promoters. This study investigated the effects of heat-killed Lactobacillus plantarumL-137 (L-137) and antibiotics as preventive and/or therapeutic substances for broilers against subclinical necrotic enteritis caused by Clostridium perfringens (CP). In total, 300 1-day-old broilers (46.13 ± 1.38 g) were randomly stocked at 10 birds pen -1  in five replicates and divided into six groups, namely T1 and T2, positive and negative control of CP challenge; T3 and T4, prevention with basal diet plus 10 and 50 mg/kg L-137; T5 and T6, prevention and treatment with basal diet plus 50 mg/kg of L-137 and bacitracin at 50 ppm, respectively. Broilers administered L-137 in T4, T5 and bacitracin in T6 showed an improved (p < 0.05) villus height/crypt depth ratio than control groups, suggesting that it might significantly boost growth performance. In contrast to bacitracin, a high dosage of L-137 significantly increased (p < 0.05) the spleen index value and the cytokine levels, as well as the expression of intestinal β-defensin genes on day 28. During the 42-day production period, broilers in T4 and T5 showed a significantly enhanced (p < 0.05) expression of cytokines, AvBD-1 and AvBD-7 on day 42 compared to the control and bacitracin groups. In particular, broilers given the L-137 diets demonstrated no cumulative mortality following CP exposure, compared to a 2% mortality in T6. Our findings provide insight into eco-friendly alternatives to antibiotics for maximizing growth performance, feed efficiency and long-term disease protection in chickens; however, this has to be proven in larger-scale commercial experiments.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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