Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study.

Autor: Alsanie I; Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.; Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Rajab S; Dental Hospital, King Abdulaziz University Hospital, Jeddah, Saudi Arabia., Cottom H; Barts Health NHS Trust, London, UK., Adegun O; University College London Hospitals NHS Foundation Trust, London, UK., Agarwal R; University College London Hospitals NHS Foundation Trust, London, UK., Jay A; University College London Hospitals NHS Foundation Trust, London, UK., Graham L; Health Sciences Building, Regional Molecular Diagnostic Service, Belfast Health and Social Care Trust, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland., James J; Health Sciences Building, Regional Molecular Diagnostic Service, Belfast Health and Social Care Trust, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland.; Precision Medicine Centre of Excellence, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland., Barrett AW; Department of Histopathology, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, RH19 3DZ, UK., van Heerden W; Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, School of Dentistry, University of Pretoria, Pretoria, South Africa., de Vito M; Department of Pathology -ULSS6 Euganea, Camposampiero, PD, Italy., Canesso A; Department of Pathology -ULSS6 Euganea, Camposampiero, PD, Italy., Adisa AO; University of Ibadan and University College Hospital Ibadan, Ibadan, Nigeria., Akinshipo AO; University of Lagos, Lagos, Nigeria.; Lagos University Teaching Hospitals, Lagos, Nigeria., Ajayi OF; University of Lagos, Lagos, Nigeria.; Lagos University Teaching Hospitals, Lagos, Nigeria., Nwoga MC; University of Nigeria Teaching Hospital, Enugu, Nigeria., Okwuosa CU; University of Nigeria Teaching Hospital, Enugu, Nigeria., Omitola OG; University of Port-Harcourt and University of Port-Harcourt Teaching Hospital, Port Harcourt, Nigeria., Orikpete EV; University of Port-Harcourt and University of Port-Harcourt Teaching Hospital, Port Harcourt, Nigeria., Soluk-Tekkesin M; Department of Tumour Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey., Bello IO; Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Qannam A; Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Gonzalez W; Facultad de Odontología, Universidad de Valparaíso, Valparaiso, Chile.; Facultad de Odontología, Universidad de los Andes, Santiago, Chile., Pérez-de-Oliveira ME; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Santos-Silva AR; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Vargas PA; Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, School of Dentistry, University of Pretoria, Pretoria, South Africa.; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Toh EW; Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK., Khurram SA; Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK. s.a.khurram@sheffield.ac.uk.
Jazyk: angličtina
Zdroj: Head and neck pathology [Head Neck Pathol] 2022 Dec; Vol. 16 (4), pp. 1043-1054. Date of Electronic Publication: 2022 May 27.
DOI: 10.1007/s12105-022-01459-0
Abstrakt: Background: Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only.
Methods: This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019.
Results: A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. The majority (68%) of the SGT presented in major and 32% in the minor glands. The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. Pleomorphic adenoma (70%), and Warthin's tumour (17%), were the most common benign tumours whereas mucoepidermoid carcinoma (26%) and adenoid cystic carcinoma (17%) were the most frequent malignant tumours.
Conclusions: This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. These findings should serve as a baseline for future studies evaluating the epidemiological landscape of these tumours.
(© 2022. The Author(s).)
Databáze: MEDLINE
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