| Autor: |
Coelho MA; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil., Jeyaraman M; Department of Orthopaedics, Faculty of Medicine-Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600095, Tamil Nadu, India., Jeyaraman N; Fellow in Joint Replacement, Department of Orthopaedics, Atlas Hospitals, Tiruchirappalli 620002, Tamil Nadu, India., Rajendran RL; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea., Sugano AA; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil., Mosaner T; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil., Santos GS; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil., Bizinotto Lana JV; Medical Specialties School Centre, Centro Universitário Max Planck, Indaiatuba 13343-060, Brazil., Lana AVSD; Medical Specialties School Centre, Centro Universitário Max Planck, Indaiatuba 13343-060, Brazil., da Fonseca LF; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil.; Department of Orthopaedics, The Federal University of São Paulo, São Paulo 04024-002, Brazil., Domingues RB; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil., Gangadaran P; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, Korea., Ahn BC; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, Korea., Lana JFSD; Department of Orthopaedics, Brazilian Institute of Regenerative Medicine, Indaiatuba 13334-170, Brazil. |
| Abstrakt: |
This study investigates the role of Sygen ® in diabetic peripheral neuropathy, a severe disease that affects the peripheral nervous system in diabetic individuals. This disorder often impacts the lower limbs, causing significant discomfort and, if left untreated, progresses into more serious conditions involving chronic ulcers and even amputation in many cases. Although there are management strategies available, peripheral neuropathies are difficult to treat as they often present multiple causes, especially due to metabolic dysfunction in diabetic individuals. Gangliosides, however, have long been studied and appreciated for their role in neurological diseases. The monosialotetrahexosylganglioside (GM1) ganglioside, popularly known as Sygen, provides beneficial effects such as enhanced neuritic sprouting, neurotrophism, neuroprotection, anti-apoptosis, and anti-excitotoxic activity, being particularly useful in the treatment of neurological complications that arise from diabetes. This product mimics the roles displayed by neurotrophins, improving neuronal function and immunomodulation by attenuating exacerbated inflammation in neurons. Furthermore, Sygen assists in axonal stabilization and keeps nodal and paranodal regions of myelin fibers organized. This maintains an adequate propagation of action potentials and restores standard peripheral nerve function. Given the multifactorial nature of this complicated disorder, medical practitioners must carefully screen the patient to avoid confusion and misdiagnosis. There are several studies analyzing the role of Sygen in neurological disorders. However, the medical literature still needs more robust investigations such as randomized clinical trials regarding the administration of this compound for diabetic peripheral neuropathies, specifically. |
