Adult Female Sleep During Hypoxic Bed Rest.

Autor:	Van Cutsem J; VIPER Research Unit, Royal Military Academy, Brussels, Belgium.; Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium., Pattyn N; VIPER Research Unit, Royal Military Academy, Brussels, Belgium.; Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium., Mairesse O; Sleep Laboratory and Unit for Chronobiology U78, Brugmann University Hospital, Vrije Universiteit Brussel, Brussels, Belgium.; Brain, Body and Cognition, Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium., Delwiche B; VIPER Research Unit, Royal Military Academy, Brussels, Belgium.; Brain, Body and Cognition, Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium., Fernandez Tellez H; VIPER Research Unit, Royal Military Academy, Brussels, Belgium., Van Puyvelde M; VIPER Research Unit, Royal Military Academy, Brussels, Belgium.; Experimental and Applied Psychology, Department of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium.; Clinical & Lifespan Psychology, Department of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium., Lacroix E; VIPER Research Unit, Royal Military Academy, Brussels, Belgium., McDonnell AC; Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia., Eiken O; Department of Environmental Physiology, Swedish Aerospace Physiology centre, Royal Institute of Technology, Stockholm, Sweden., Mekjavic IB; Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2022 May 10; Vol. 16, pp. 852741. Date of Electronic Publication: 2022 May 10 (Print Publication: 2022).
DOI:	10.3389/fnins.2022.852741
Abstrakt:	Purpose: Hypobaric hypoxic habitats are currently being touted as a potential solution to minimise decompression procedures in preparation for extra vehicular activities during future space missions. Since astronauts will live in hypoxic environments for the duration of such missions, the present study sought to elucidate the separate and combined effects of inactivity [simulated with the experimental bed rest (BR) model] and hypoxia on sleep characteristics in women. Methods: Twelve women (Age = 27 ± 3 year) took part in three 10-day interventions, in a repeated measures cross-over counterbalanced design: (1) normobaric normoxic BR (NBR), (2) normobaric hypoxic BR (HBR; simulated altitude of 4,000 m), and (3) normobaric hypoxic ambulatory (HAMB; 4,000 m) confinement, during which sleep was assessed on night 1 and night 10 with polysomnography. In addition, one baseline sleep assessment was performed. This baseline assessment, although lacking a confinement aspect, was included statistically as a fourth comparison (i.e., pseudo normobaric normoxic ambulatory; pNAMB) in the present study. Results: Hypoxia decreased sleep efficiency ( p = 0.019), increased N1% sleep ( p = 0.030), decreased N3 sleep duration ( p = 0.003), and increased apnea hypopnea index ( p < 0.001). BR impaired sleep maintenance, efficiency, and architecture [e.g., N2% sleep increased ( p = 0.033)]. Specifically, for N3% sleep, the effects of partial pressure of oxygen and activity interacted. Hypoxia decreased N3% sleep both when active (pNAMB vs HAMB; p < 0.001) and inactive (NBR vs HBR; p = 0.021), however, this decrease was attenuated in the inactive state (-3.8%) compared to the active state (-10.2%). Conclusion: A 10-day exposure to hypoxia and BR negatively impacted sleep on multiple levels as in macrostructure, microstructure and respiratory functioning. Interestingly, hypoxia appeared to have less adverse effects on sleep macrostructure while the participants were inactive (bed ridden) compared to when ambulatory. Data were missing to some extent (i.e., 20.8%). Therefore, multiple imputation was used, and our results should be considered as exploratory. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Van Cutsem, Pattyn, Mairesse, Delwiche, Fernandez Tellez, Van Puyvelde, Lacroix, McDonnell, Eiken and Mekjavic.)
Databáze:	MEDLINE
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