Serotonin transporter gene methylation and emotional regulation in preschool children born preterm: A longitudinal evaluation of the role of negative emotionality in infancy.

Autor: Mascheroni E; Scientific Institute IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy., Schiavolin P; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Mariani Wigley ILC; Scientific Institute IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy.; Department of Developmental and Social Psychology, University of Padua, Padua, Italy., Giorda R; Scientific Institute IRCCS E. Medea, Molecular Biology Lab, Bosisio Parini, Lecco, Italy., Pozzoli U; Scientific Institute IRCCS E. Medea, Computational Biology, Bosisio Parini, Italy., Morandi F; UOC Pediatria-Neonatologia, ASST Lecco - Ospedale San L. Mandic, Merate, Lecco, Italy., Fontana C; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Mosca F; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Fumagalli M; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Montirosso R; Scientific Institute IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Lecco, Italy.
Jazyk: angličtina
Zdroj: Infant mental health journal [Infant Ment Health J] 2022 Jul; Vol. 43 (4), pp. 589-596. Date of Electronic Publication: 2022 May 26.
DOI: 10.1002/imhj.21990
Abstrakt: The aim of the study was to assess the contribution of negative emotionality at 3 months (T1) and serotonin transporter gene (SLC6A4) DNA methylation at 4.5 years of age (T2) to emotion regulation in pre-schoolers born very preterm and full-term. Forty one children (n = 21 born very preterm, n = 20 born full-term) participated in the study. Fretful behavior was assessed at T1 in response to the Face-to-FaceStill-Face (FFSF) paradigm. At T2, SLC6A4 DNA methylation was analyzed and emotion regulation was assessed using an observational procedure (i.e., the Pre-schooler Regulation of Emotional Stress, PRES). The very preterm group displayed higher emotion dysregulation during the PRES Reactivity phase than the full-term group. Higher levels of fretful behavior at 3 months were associated with greater emotional distress only for very preterm children with higher methylation at T2. No significant associations emerged in the full-term group. Despite current findings cannot be generalized owing to the relatively small sample size, this work provides preliminary longitudinal evidence about the link between negative emotionality during infancy, stress-linked epigenetic status at 4.5 years and emotion dysregulation in preschoolers born preterm.
(© 2022 Michigan Association for Infant Mental Health.)
Databáze: MEDLINE
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