Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins.

Autor: Popova NA; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.; Novosibirsk National Research State University, Novosibirsk, Russia., Nikolin VP; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Kaledin VI; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Serova IA; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Matyunina EA; Biotechnology Company, Moscow, Russia., Bakarev MA; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Lushnikova EL; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. pathol@inbox.ru., Vologodskii AN; Biotechnology Company, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 May; Vol. 173 (1), pp. 105-109. Date of Electronic Publication: 2022 May 27.
DOI: 10.1007/s10517-022-05502-6
Abstrakt: We studied the effect of a new targeted drug Pefagtal that represents a conjugate in which the MS2 phage filled with a substance toxic to cells (thallium salts) is covalently linked to peptides containing the RGD motif. The antitumor and pronounced antimetastatic effects of Pefagtal were demonstrated on transplanted mouse tumors differing in histological type and status of metastasis: Krebs-2 ascites adenocarcinoma of the mammary gland, Lewis lung adenocarcinoma, hepatoma-29, and lung adenocarcinoma. It is assumed that the RGD motif mediates primary binding of the construct to αvβ3 and αvβ5 integrins that are predominantly overexpressed in the endothelial cells of tumor blood vessels and in tumor and metastatic cells.
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Databáze: MEDLINE
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