Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues.

Autor: Prominski A; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; The James Franck Institute, The University of Chicago, Chicago, IL, USA.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA., Shi J; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; The James Franck Institute, The University of Chicago, Chicago, IL, USA.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA., Li P; The Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA., Yue J; Department of Chemistry, The University of Chicago, Chicago, IL, USA., Lin Y; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; The James Franck Institute, The University of Chicago, Chicago, IL, USA.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA., Park J; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; The James Franck Institute, The University of Chicago, Chicago, IL, USA.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA., Tian B; Department of Chemistry, The University of Chicago, Chicago, IL, USA. btian@uchicago.edu.; The James Franck Institute, The University of Chicago, Chicago, IL, USA. btian@uchicago.edu.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. btian@uchicago.edu., Rotenberg MY; Department of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, Israel. hemir@bm.technion.ac.il.
Jazyk: angličtina
Zdroj: Nature materials [Nat Mater] 2022 Jun; Vol. 21 (6), pp. 647-655. Date of Electronic Publication: 2022 May 26.
DOI: 10.1038/s41563-022-01249-7
Abstrakt: Homo- and heterojunctions play essential roles in semiconductor-based devices such as field-effect transistors, solar cells, photodetectors and light-emitting diodes. Semiconductor junctions have been recently used to optically trigger biological modulation via photovoltaic or photoelectrochemical mechanisms. The creation of heterojunctions typically involves materials with different doping or composition, which leads to high cost, complex fabrications and potential side effects at biointerfaces. Here we show that a porosity-based heterojunction, a largely overlooked system in materials science, can yield an efficient photoelectrochemical response from the semiconductor surface. Using self-limiting stain etching, we create a nanoporous/non-porous, soft-hard heterojunction in p-type silicon within seconds under ambient conditions. Upon surface oxidation, the heterojunction yields a strong photoelectrochemical response in saline. Without any interconnects or metal modifications, the heterojunction enables efficient non-genetic optoelectronic stimulation of isolated rat hearts ex vivo and sciatic nerves in vivo with optical power comparable to optogenetics, and with near-infrared capabilities.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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