An electrostatic self-assembly approach to prepare tebuconazole nanoparticles with improved sustained release and enhanced antifungal activity.

Autor: Shi W; Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, PR China., Li S; Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, PR China., Wang X; Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, PR China., Li S; Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, PR China. Electronic address: lishujing@th.btbu.edu.cn., Zhang X; Sino-Agri Leading Biosciences Co., LTD., Beijing 100052, PR China. Electronic address: zhangxiaojun@sino-agri.com., Hou F; Fujian Lord Biological Technology Co., LTD., Fujian 365300, PR China.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2022 Aug; Vol. 216, pp. 112587. Date of Electronic Publication: 2022 May 21.
DOI: 10.1016/j.colsurfb.2022.112587
Abstrakt: Compared with the traditional pesticides, the nanopesticides (NPs) exhibit better sustained release performance, higher utilization efficiency and reduction of environmental pollution. In this study, the antifungal tebuconazole (TEB) loaded nanoparticles (TEB NPs) were prepared by electrostatic self-assembly of the positively charged poly dimethyl diallyl ammonium chloride (PDADMAC) and sulfobutylether-β-cyclodextrin (SCD) inclusion complex (TEB-SCD) with negative charge. The water solubility and thermal stability of TEB were significantly improved after forming the inclusion complex. The blank NPs and TEB NPs were both characterized by particle size, zeta potential, scanning electron microscopy (SEM), sustained release and antifungal activity. The average particle size of the TEB NPs were 411.75 ± 61.65 nm, and the polydispersity index (PDI) showed low values (< 0.3). The TEB NPs were stable for at least 28 days at 25 °C. Compared with pure TEB, TEB NPs showed the sustained release properties. In addition, TEB NPs exhibited better antifungal activity than TEB industrial concentrate (TC, 98%) and commercially available TEB suspension concentrate (SC) with the 96.33 ± 13.52% antifungal rate of fusarium graminearum. The results indicated that the TEB NPs can improve the antifungal activity and reduce environmental pollution.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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