Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis.

Autor:	Dzinamarira T; School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa; ICAP at Columbia University, Harare, Zimbabwe. Electronic address: u19395419@up.ac.za., Murewanhema G; Unit of Obstetrics and Gynaecology, Department of Primary Health Care Sciences, Faculty of Medicine and Health Sciences, University of Zimbabwe, Zimbabwe., Chitungo I; Faculty of Medicine, College of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Ngara B; Faculty of Medicine, College of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Nkambule SJ; Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban 4001, South Africa., Madziva R; University of Nottingham, UK., Herrera H; University of Portsmouth, UK., Mukwenha S; ICAP at Columbia University, Harare, Zimbabwe., Cuadros DF; University of Cincinnati, USA., Iradukunda PG; London School of Hygiene and Tropical Medicine, University of London, London, UK., Mashora M; Department of Public Health, Mount Kenya University, Kigali, Rwanda., Tungwarara N; Department of Health Studies, University of South Africa, South Africa., Rwibasira GN; Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda., Musuka G; ICAP at Columbia University, Harare, Zimbabwe.
Jazyk:	angličtina
Zdroj:	Journal of infection and public health [J Infect Public Health] 2022 Jun; Vol. 15 (6), pp. 654-661. Date of Electronic Publication: 2022 May 16.
DOI:	10.1016/j.jiph.2022.05.006
Abstrakt:	Background: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger's test was employed to determine the risk of bias. Results: A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86-1.32). The between-studies heterogeneity was substantial (I 2 = 91%, P < 0.01), while the risk of publication bias was not significant. Conclusion: Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection. Competing Interests: Competing interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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