Microglia-mediated degradation of perineuronal nets promotes pain.

Autor: Tansley S; Department of Anesthesia, McGill University, Montreal, QC, Canada.; Department of Psychology, Faculty of Science, McGill University, Montreal, QC, Canada., Gu N; Department of Anesthesia, McGill University, Montreal, QC, Canada., Guzmán AU; Department of Anesthesia, McGill University, Montreal, QC, Canada., Cai W; Department of Anesthesia, McGill University, Montreal, QC, Canada., Wong C; Department of Anesthesia, McGill University, Montreal, QC, Canada., Lister KC; Department of Anesthesia, McGill University, Montreal, QC, Canada., Muñoz-Pino E; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Québec, QC, Canada., Yousefpour N; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada., Roome RB; Institut de Recherches Cliniques de Montreal (IRCM), Montreal, QC, Canada., Heal J; Department of Anesthesia, McGill University, Montreal, QC, Canada., Wu N; Department of Anesthesia, McGill University, Montreal, QC, Canada., Castonguay A; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Québec, QC, Canada., Lean G; Department of Physiology, McGill University, Montreal, QC, Canada., Muir EM; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Kania A; Institut de Recherches Cliniques de Montreal (IRCM), Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada., Prager-Khoutorsky M; Department of Physiology, McGill University, Montreal, QC, Canada., Zhang J; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; Faculty of Dental Medicine and Oral Health Sciences, Montreal, QC, Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Gkogkas CG; Biomedical Research Institute, Foundation for Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece., Fawcett JW; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Centre for Reconstructive Neuroscience, Institute for Experimental Medicine CAS, Prague, Czech Republic., Diatchenko L; Department of Anesthesia, McGill University, Montreal, QC, Canada.; Faculty of Dental Medicine and Oral Health Sciences, Montreal, QC, Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Ribeiro-da-Silva A; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., De Koninck Y; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Québec, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Mogil JS; Department of Anesthesia, McGill University, Montreal, QC, Canada.; Department of Psychology, Faculty of Science, McGill University, Montreal, QC, Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Khoutorsky A; Department of Anesthesia, McGill University, Montreal, QC, Canada.; Faculty of Dental Medicine and Oral Health Sciences, Montreal, QC, Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2022 Jul; Vol. 377 (6601), pp. 80-86. Date of Electronic Publication: 2022 May 26.
DOI: 10.1126/science.abl6773
Abstrakt: Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.
Databáze: MEDLINE
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