Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses.
Autor: | Elsamadicy EA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA., Thompson LP; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. lthompson1@umm.edu. |
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Jazyk: | angličtina |
Zdroj: | Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2022 Oct; Vol. 29 (10), pp. 3015-3025. Date of Electronic Publication: 2022 May 26. |
DOI: | 10.1007/s43032-022-00979-y |
Abstrakt: | Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a major role in preservation of placental growth and function. We investigated the effects of chronic hypoxia and sex on protein expression of the IGF-2 pathway in placentas selected from asymmetric-FGR fetuses. Time-mated pregnant guinea pigs were assigned to normoxia (NMX, 21% O (© 2022. Society for Reproductive Investigation.) |
Databáze: | MEDLINE |
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