The Role of β-Adrenergic Receptors in the Regulation of the Functions of Innate Immune Cells during Cold Stress In Vivo.

Autor: Gein SV; Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences - Branch of Perm Federal Research Center, Ural Division of the Russian Academy of Sciences, Perm, Russia. gein@iegm.ru.; Perm State National Research University, Perm, Russia. gein@iegm.ru., Karnaukhova AV; Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences - Branch of Perm Federal Research Center, Ural Division of the Russian Academy of Sciences, Perm, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 May; Vol. 173 (1), pp. 72-76. Date of Electronic Publication: 2022 May 26.
DOI: 10.1007/s10517-022-05496-1
Abstrakt: It was found that 10-min cold stress enhanced stimulated production of ROS, while 60-min cold stress increased both spontaneous and stimulated ROS production by peritoneal macrophages. β-Adrenergic receptor blockade leveled the effect of 10-min stress in stimulated cultures and the effect of 60-min stress in spontaneous cultures. None variants of cold stress affected spontaneous and stimulated production of IL-1β. We observed an increase in the production of IL-1β in stimulated cultures from animals subjected to 10- and 60-min stress against the background of propranolol. At the same time, both variants of cold exposure, irrespective of β-adrenergic receptor blockade, stimulated IL-10 synthesis in spontaneous and activated samples. None of the used models of cold exposure affected the phagocytic activity of peritoneal macrophages. Thus, β-adrenergic receptors are directly involved in the regulation of cytokine production and microbicidal potential of macrophages in acute cold stress.
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Databáze: MEDLINE
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