Amplification of cell signaling and disease resistance by an immunity receptor Ve1Ve2 heterocomplex in plants.

Autor: Kalischuk M; Department of Agriculture and Agri-Food Canada, Lethbridge, AB, T1J 4B1, Canada.; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.; Department of Plant Agriculture, University of Guelph, Guelph, ON, N1G 2W1, Canada., Müller B; Department of Agriculture and Agri-Food Canada, Lethbridge, AB, T1J 4B1, Canada.; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Schlossplatz 8, 48143, Münster, Germany., Fusaro AF; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.; Institute of Medical Biochemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-590, Brazil., Wijekoon CP; Department of Agriculture and Agri-Food Canada, Lethbridge, AB, T1J 4B1, Canada.; Canadian Centre for Agri-Food Research in Health and Medicine, 351 Taché Avenue, R2020, Winnipeg, MB, R2H 2A6, Canada., Waterhouse PM; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.; School of Earth, Environmental and Biological sciences, Queensland University of Technology, Brisbane, QLD, 4001, Australia., Prüfer D; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Schlossplatz 8, 48143, Münster, Germany. dpruefer@uni-muenster.de.; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, 48143, Münster, Germany. dpruefer@uni-muenster.de., Kawchuk L; Department of Agriculture and Agri-Food Canada, Lethbridge, AB, T1J 4B1, Canada. lawrence.kawchuk@canada.ca.; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia. lawrence.kawchuk@canada.ca.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2022 May 25; Vol. 5 (1), pp. 497. Date of Electronic Publication: 2022 May 25.
DOI: 10.1038/s42003-022-03439-0
Abstrakt: Immunity cell-surface receptors Ve1 and Ve2 protect against fungi of the genus Verticillium causing early dying, a worldwide disease in many crops. Characterization of microbe-associated molecular pattern immunity receptors has advanced our understanding of disease resistance but signal amplification remains elusive. Here, we report that transgenic plants expressing Ve1 and Ve2 together, reduced pathogen titres by a further 90% compared to plants expressing only Ve1 or Ve2. Confocal and immunoprecipitation confirm that the two receptors associate to form heteromeric complexes in the absence of the ligand and positively regulate signaling. Bioassays show that the Ve1Ve2 complex activates race-specific amplified immunity to the pathogen through a rapid burst of reactive oxygen species (ROS). These results indicate a mechanism by which the composition of a cell-surface receptor heterocomplex may be optimized to increase immunity against devastating plant diseases.
(© 2022. Crown.)
Databáze: MEDLINE
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