Effects of Noise Exposure and Aging on Behavioral Tone Detection in Quiet and Noise by Mice.

Autor:	Burke K; Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260.; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Screven LA; Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260.; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Kobrina A; Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260., Charlton PE; Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260., Schrode K; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Villavisanis DF; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Dent ML; Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260., Lauer AM; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205 alauer2@jhmi.edu.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2022 Jun 10; Vol. 9 (3). Date of Electronic Publication: 2022 Jun 10 (Print Publication: 2022).
DOI:	10.1523/ENEURO.0391-21.2022
Abstrakt:	Aging leads to degeneration of the peripheral and central auditory systems, hearing loss, and difficulty understanding sounds in noise. Aging is also associated with changes in susceptibility to or recovery from damaging noise exposures, although the effects of the interaction between acute noise exposure and age on the perception of sounds are not well studied. We tested these effects in the CBA/CaJ mouse model of age-related hearing loss using operant conditioning procedures before and after noise exposure and longitudinally measured changes in their sensitivity for detecting tones in quiet or noise backgrounds. Cochleae from a subset of the behaviorally tested mice were immunolabeled to examine organ of Corti damage relative to what is expected based on aging alone. Mice tested in both quiet and noise background conditions experienced worse behavioral sensitivity immediately after noise exposure, but mice exposed at older ages generally showed greater threshold shifts and reduced recovery over time. Surprisingly, day-to-day stability in thresholds was markedly higher for mice detecting signals in the presence of a noise masker compared with detection in quiet conditions. Cochlear analysis revealed decreases in the total number of outer hair cells (OHCs) and the number of ribbons per inner cell in high-frequency regions in aged, noise-exposed mice relative to aging alone. Our findings build on previous work showing interactions between age and noise exposure and add that background noise can increase the stability of behavioral hearing sensitivity after noise damage. (Copyright © 2022 Burke et al.)
Databáze:	MEDLINE
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