Impact of High Cardiovascular Risk on Hospital Mortality in Intensive Care Patients Hospitalized for COVID-19.

Autor:	Gomes BFO; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil.; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Petriz JLF; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Menezes IRR; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Azevedo AS; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Silva TMBD; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Silva VL; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Peres LS; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Pereira DFP; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Dutra GP; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil.; Universidade Federal do Rio de Janeiro - ICES Instituto do Coração Edson Saad, Rio de Janeiro, RJ - Brasil., Paula SAM; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Mendes BFDS; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil., Carmo Junior PRD; Barra D'Or Hospital, Rio de Janeiro, RJ - Brasil.; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Pereira BB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Oliveira GMM; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2022 May; Vol. 118 (5), pp. 927-934.
DOI:	10.36660/abc.20210349
Abstrakt:	Background: Some studies have shown a higher prevalence of deaths in patients with cardiovascular risk factors (CRF) during hospitalization for COVID-19. Objectives: To assess the impact of high cardiovascular risk in patients hospitalized in intensive care for COVID-19. Methods: Retrospective study with patients admitted to an intensive care unit, with a diagnosis of COVID-19 confirmed by RT-PCR, and with at least one troponin measurement during hospitalization. The criteria for defining high cardiovascular risk (HCR) patients were: history of established cardiovascular disease (myocardial infarction, stroke, or peripheral arterial disease), diabetes, chronic kidney disease with clearance < 60ml/min, or presence of 3 CRFs (hypertension, smoking, dyslipidemia, or age > 65 years). The primary outcome of this study is all-cause in-hospital mortality. P<0.05 was considered significant. Results: This study included 236 patients, mean age = 61.14±16.2 years, with 63.1% men, 55.5% hypertensive, and 33.1% diabetic; 47.4% of the patients also presented HCR. A significant increase in mortality was observed as the number of risk factors increased (0 FRC: 5.9%; 1 FRC: 17.5%; 2 FRC: 32.2% and ≥3 FRC: 41.2%; p=0.001). In the logistic regression adjusted for severity (SAPS3 score), the HCR and myocardial injury group had a higher occurrence of in-hospital mortality (OR 40.38; 95% CI 11.78-138.39). Patients without HCR but with myocardial injury also exhibited a significant association with the primary outcome (OR 16.7; 95% CI 4.45-62.74). Conclusion: In patients hospitalized in intensive care for COVID-19, HCR impacts in-hospital mortality only in patients with myocardial injury.
Databáze:	MEDLINE
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