Trends in social exposure to SARS-Cov-2 in France. Evidence from the national socio-epidemiological cohort-EPICOV.

Autor: Warszawski J; INSERM CESP U1018, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; AP-HP Epidemiology and Public Health Service, Service, Hôpitaux Universitaires Paris-Saclay, Le Kremlin-Bicêtre, France., Meyer L; INSERM CESP U1018, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; AP-HP Epidemiology and Public Health Service, Service, Hôpitaux Universitaires Paris-Saclay, Le Kremlin-Bicêtre, France., Franck JE; Iris-Institut de Recherche Interdisciplinaire sur les enjeux sociaux, Inserm, Aubervilliers, France., Rahib D; Santé Publique France, Saint-Maurice, France., Lydié N; Santé Publique France, Saint-Maurice, France., Gosselin A; French Institute for Demographic Studies (INED), Aubervilliers, France.; French Collaborative Institute on Migrations/CNRS, Aubervilliers, France., Counil E; French Institute for Demographic Studies (INED), Aubervilliers, France., Kreling R; INSERM CESP U1018, Université Paris-Saclay, Le Kremlin-Bicêtre, France., Novelli S; INSERM CESP U1018, Université Paris-Saclay, Le Kremlin-Bicêtre, France., Slama R; Institut thématique de Santé Publique, INSERM, Paris, France.; Inserm, CNRS, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, University Grenoble Alpes, Grenoble, France., Raynaud P; DREES-Direction de la Recherche, des Etudes, de l'évaluation et des statistiques, Paris, France., Bagein G; DREES-Direction de la Recherche, des Etudes, de l'évaluation et des statistiques, Paris, France., Costemalle V; DREES-Direction de la Recherche, des Etudes, de l'évaluation et des statistiques, Paris, France., Sillard P; Institut National de la statistique et des études économiques, Montrouge, France., Fourie T; Unité des Virus Emergents, UVE, Aix Marseille Univ, INSERM 1207, IRD 190, Marseille, France., de Lamballerie X; Unité des Virus Emergents, UVE, Aix Marseille Univ, INSERM 1207, IRD 190, Marseille, France., Bajos N; Iris-Institut de Recherche Interdisciplinaire sur les enjeux sociaux, Inserm, Aubervilliers, France.; Ecole des Hautes Etudes en Sciences Sociales, Paris, France.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 May 25; Vol. 17 (5), pp. e0267725. Date of Electronic Publication: 2022 May 25 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0267725
Abstrakt: Background: We aimed to study whether social patterns of exposure to SARS-CoV-2 infection changed in France throughout the year 2020, in light to the easing of social contact restrictions.
Methods: A population-based cohort of individuals aged 15 years or over was randomly selected from the national tax register to collect socio-economic data, migration history, and living conditions in May and November 2020. Home self-sampling on dried blood was proposed to a 10% random subsample in May and to all in November. A positive anti-SARS-CoV-2 ELISA IgG result against the virus spike protein (ELISA-S) was the primary outcome. The design, including sampling and post-stratification weights, was taken into account in univariate and multivariate analyses.
Results: Of the 134,391 participants in May, 107,759 completed the second questionnaire in November, and respectively 12,114 and 63,524 were tested. The national ELISA-S seroprevalence was 4.5% [95%CI: 4.0%-5.1%] in May and 6.2% [5.9%-6.6%] in November. It increased markedly in 18-24-year-old population from 4.8% to 10.0%, and among second-generation immigrants from outside Europe from 5.9% to 14.4%. This group remained strongly associated with seropositivity in November, after controlling for any contextual or individual variables, with an adjusted OR of 2.1 [1.7-2.7], compared to the majority population. In both periods, seroprevalence remained higher in healthcare professions than in other occupations.
Conclusion: The risk of Covid-19 infection increased among young people and second-generation migrants between the first and second epidemic waves, in a context of less strict social restrictions, which seems to have reinforced territorialized socialization among peers.
Competing Interests: The authors have declared that no competing interests exist
Databáze: MEDLINE
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