Repurposing drugs to treat cardiovascular disease in the era of precision medicine.

Autor: Abdelsayed M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine, Stanford University, Stanford, CA, USA., Kort EJ; DeVos Cardiovascular Program Spectrum Health & Van Andel Institute, Grand Rapids, MI, USA., Jovinge S; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. stefan.jovinge@skane.se.; DeVos Cardiovascular Program Spectrum Health & Van Andel Institute, Grand Rapids, MI, USA. stefan.jovinge@skane.se.; Department of Medicine, University of Texas Southwestern, Dallas, TX, USA. stefan.jovinge@skane.se.; Department of Clinical Sciences, Scania University Hospital, Lund University, Lund, Sweden. stefan.jovinge@skane.se., Mercola M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. mmercola@stanford.edu.; Department of Medicine, Stanford University, Stanford, CA, USA. mmercola@stanford.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Cardiology [Nat Rev Cardiol] 2022 Nov; Vol. 19 (11), pp. 751-764. Date of Electronic Publication: 2022 May 23.
DOI: 10.1038/s41569-022-00717-6
Abstrakt: Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to produce a new drug. To date, drug repurposing for cardiovascular indications has been opportunistic and driven by knowledge of disease mechanisms or serendipitous observation rather than by systematic endeavours to match an existing drug to a new indication. Innovations in two areas of personalized medicine - computational approaches to associate drug effects with disease signatures and predictive model systems to screen drugs for disease-modifying activities - support efforts that together create an efficient pipeline to systematically repurpose drugs to treat cardiovascular disease. Furthermore, new experimental strategies that guide the medicinal chemistry re-engineering of drugs could improve repurposing efforts by tailoring a medicine to its new indication. In this Review, we summarize the historical approach to repurposing and discuss the technological advances that have created a new landscape of opportunities.
(© 2022. Springer Nature Limited.)
Databáze: MEDLINE
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