Origins of direction selectivity in the primate retina.

Autor: Kim YJ; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA., Peterson BB; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA., Crook JD; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA., Joo HR; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA., Wu J; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Puller C; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA., Robinson FR; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA.; Washington National Primate Research Center, Seattle, WA, 98195, USA., Gamlin PD; Department of Ophthalmology and Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294-4390, USA., Yau KW; Departments of Neuroscience and Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205-2185, USA., Viana F; Institute of Neuroscience, UMH-CSIC, San Juan de Alicante, 03550, Spain., Troy JB; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Smith RG; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, 19104, USA., Packer OS; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA., Detwiler PB; Department of Physiology and Biophysics, University of Washington, Seattle, WA, 98195, USA., Dacey DM; Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA. dmd@uw.edu.; Washington National Primate Research Center, Seattle, WA, 98195, USA. dmd@uw.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 May 23; Vol. 13 (1), pp. 2862. Date of Electronic Publication: 2022 May 23.
DOI: 10.1038/s41467-022-30405-5
Abstrakt: From mouse to primate, there is a striking discontinuity in our current understanding of the neural coding of motion direction. In non-primate mammals, directionally selective cell types and circuits are a signature feature of the retina, situated at the earliest stage of the visual process. In primates, by contrast, direction selectivity is a hallmark of motion processing areas in visual cortex, but has not been found in the retina, despite significant effort. Here we combined functional recordings of light-evoked responses and connectomic reconstruction to identify diverse direction-selective cell types in the macaque monkey retina with distinctive physiological properties and synaptic motifs. This circuitry includes an ON-OFF ganglion cell type, a spiking, ON-OFF polyaxonal amacrine cell and the starburst amacrine cell, all of which show direction selectivity. Moreover, we discovered that macaque starburst cells possess a strong, non-GABAergic, antagonistic surround mediated by input from excitatory bipolar cells that is critical for the generation of radial motion sensitivity in these cells. Our findings open a door to investigation of a precortical circuitry that computes motion direction in the primate visual system.
(© 2022. The Author(s).)
Databáze: MEDLINE
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