Effects of intravenous acepromazine and butorphanol on propofol dosage for induction of anesthesia in healthy Beagle dogs.

Autor:	Dantino SC; Department of Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN, USA. Electronic address: sdantino12@gmail.com., Kleine SA; Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN, USA., Smith CK; Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN, USA., Smith SM; College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA., Zhu X; Office of Information and Technology, University of Tennessee, Knoxville, TN, USA., Seddighi R; Department of Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN, USA.
Jazyk:	angličtina
Zdroj:	Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2022 Jul; Vol. 49 (4), pp. 354-363. Date of Electronic Publication: 2022 Mar 15.
DOI:	10.1016/j.vaa.2022.03.002
Abstrakt:	Objective: To determine the effects of intravenous (IV) premedication with acepromazine, butorphanol or their combination, on the propofol anesthetic induction dosage in dogs. Study Design: Prospective, blinded, Latin square design. Animals: A total of three male and three female, healthy Beagle dogs, aged 3.79 ± 0.02 years, weighing 10.6 ± 1.1 kg, mean ± standard deviation. Methods: Each dog was assigned to one of six IV treatments weekly: 0.9% saline (treatment SAL), low-dose acepromazine (0.02 mg kg -1 ; treatment LDA), high-dose acepromazine (0.04 mg kg -1 ; treatment HDA), low-dose butorphanol (0.2 mg kg -1 ; treatment LDB), high-dose butorphanol (0.4 mg kg -1 ; treatment HDB); and a combination of acepromazine (0.02 mg kg -1 ) with butorphanol (0.2 mg kg -1 ; treatment ABC). Physiologic variables and sedation scores were collected at baseline and 10 minutes after premedication. Then propofol was administered at 1 mg kg -1 IV over 15 seconds, followed by boluses (0.5 mg kg -1 over 5 seconds) every 15 seconds until intubation. Propofol dose, physiologic variables, recovery time, recovery score and adverse effects were monitored and recorded. Data were analyzed using mixed-effects anova (p < 0.05). Results: Propofol dosage was lower in all treatments than in treatment SAL (4.4 ± 0.5 mg kg -1 ); the largest decrease was recorded in treatment ABC (1.7 ± 0.3 mg kg -1 ). Post induction mean arterial pressures (MAPs) were lower than baseline values of treatments LDA, HDA and ABC. Apnea and hypotension (MAP < 60 mmHg) developed in some dogs in all treatments with the greatest incidence of hypotension in treatment ABC (4/6 dogs). Conclusions and Clinical Relevance: Although the largest decrease in propofol dosage required for intubation was after IV premedication with acepromazine and butorphanol, hypotension and apnea still occurred. (Copyright © 2022. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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