Neuromuscular Aging: A Case for the Neuroprotective Effects of Dancing.

Autor:	Franchi MV; Department of Biomedical Sciences, University of Padova, Padua, Italy, martino.franchi@unipd.it.; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK, martino.franchi@unipd.it.; CIR-MYO Myology Center, University of Padova, Padua, Italy, martino.franchi@unipd.it., Badiali F; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK., Sarto F; Department of Biomedical Sciences, University of Padova, Padua, Italy., Müller P; German Center for Neurodegenrative Disseases (DZNE), Magdeburg, Germany.; Department of Internal Medicine, Division of Cardiology, Angiology and Intensive Medical Care, Otto-von-Guericke University, Magdeburg, Germany., Müller NG; German Center for Neurodegenrative Disseases (DZNE), Magdeburg, Germany.; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.; Center for Behavioral Brain Science (CBBS), Magdeburg, Germany., Rehfeld K; Institute for Sport Science, Otto-von-Guericke University, Magdeburg, Germany., Monti E; Department of Biomedical Sciences, University of Padova, Padua, Italy.; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK.; Department of Neurosciences, Imaging and Clinical Science, University of Chieti 'G. D'annunzio', Chieti, Italy., Rankin D; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK., Longo S; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK.; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy., Lund J; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK., Hökelmann A; Department of Internal Medicine, Division of Cardiology, Angiology and Intensive Medical Care, Otto-von-Guericke University, Magdeburg, Germany., Narici M; Department of Biomedical Sciences, University of Padova, Padua, Italy.; MRC-ARUK Centre for Musculoskeletal Ageing, University of Nottingham, Derby, UK.; CIR-MYO Myology Center, University of Padova, Padua, Italy.
Jazyk:	angličtina
Zdroj:	Gerontology [Gerontology] 2023; Vol. 69 (1), pp. 73-81. Date of Electronic Publication: 2022 May 23.
DOI:	10.1159/000524843
Abstrakt:	Aim: We planned a cross-sectional investigation (study 1) and a longitudinal training intervention (study 2) to investigate whether recreational dancing affords greater neuroprotective effects against age-related neuromuscular junction (NMJ) degeneration compared to general fitness exercise training. Methods: In study 1, we recruited 19 older volunteers regularly practising dancing (older dancers [OD]) and 15 recreationally physically active older individuals (OA) and physical performance, muscle morphology, muscle function, and NMJ stability (from serum C-terminal agrin fragment [CAF] concentration) were assessed. In study 2, employing a longitudinal study design in a different cohort (composed of 37 older adults), we aimed to study whether a 6-month dancing intervention decreased CAF concentration compared to general fitness exercise training in older adults. Results: Our findings show that OD had a lower CAF concentration (suggesting an increased NMJ stability) compared to OA. This result was accompanied by superior functional performance despite no differences in muscle size. In study 2, we observed a reduction in CAF concentration only in the dancing group. Conclusion: Overall, these findings suggest that dancing is an effective training modality to promote neuroprotection and increase muscle function in healthy older individuals. (© 2022 S. Karger AG, Basel.)
Databáze:	MEDLINE
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