Functional Alterations Due to COVID-19 Lung Lesions-Lessons From a Multicenter V/Q Scan-Based Registry.

Autor:	Bonnefoy PB; From the Service de Médecine Nucléaire, CHU de Saint-Étienne, Saint-Étienne., Bahloul A; Service de Médecine Nucléaire, CHRU Nancy, Nancy., Denizot B; Service de Médecine Nucléaire, Centre Hospitalier Alpes Léman, Contamine-sur-Arve., Barres B; Service de Médecine Nucléaire, Centre Jean Perrin, Clermont-Ferrand., Moreau-Triby C; Service de Médecine Nucléaire, Hospices Civils de Lyon, Lyon., Girma A; Service de Médecine Nucléaire, Hôpital Foch, Suresnes., Pallardy A; Service de Médecine Nucléaire, CHU de Nantes, Nantes., Ceyra Q; Centre d'Imagerie Fonctionnelle, Bordeaux., Sarda-Mantel L; Service de Médecine Nucléaire, Hôpital Lariboisière, APHP, Paris., Razzouk-Cadet M; Service de Medecine Nucléaire, CHU Nice, Nice., Zsigmond R; Centre d'Imagerie Nucléaire, Annecy., Cachin F; Service de Médecine Nucléaire, Centre Jean Perrin, Clermont-Ferrand., Karcher G; Service de Médecine Nucléaire, CHRU Nancy, Nancy., Salaun PY; Service de Médecine Nucléaire, Université Européenne de Bretagne, Université de Brest, EA3878 (GETBO) IFR 148, CHRU de Brest, Brest, France., Le Roux PY; Service de Médecine Nucléaire, Université Européenne de Bretagne, Université de Brest, EA3878 (GETBO) IFR 148, CHRU de Brest, Brest, France.
Jazyk:	angličtina
Zdroj:	Clinical nuclear medicine [Clin Nucl Med] 2022 Aug 01; Vol. 47 (8), pp. e540-e547. Date of Electronic Publication: 2022 May 19.
DOI:	10.1097/RLU.0000000000004261
Abstrakt:	Purpose: In coronavirus disease 2019 (COVID-19) patients, clinical manifestations as well as chest CT lesions are variable. Lung scintigraphy allows to assess and compare the regional distribution of ventilation and perfusion throughout the lungs. Our main objective was to describe ventilation and perfusion injury by type of chest CT lesions of COVID-19 infection using V/Q SPECT/CT imaging. Patients and Methods: We explored a national registry including V/Q SPECT/CT performed during a proven acute SARS-CoV-2 infection. Chest CT findings of COVID-19 disease were classified in 3 elementary lesions: ground-glass opacities, crazy-paving (CP), and consolidation. For each type of chest CT lesions, a semiquantitative evaluation of ventilation and perfusion was visually performed using a 5-point scale score (0 = normal to 4 = absent function). Results: V/Q SPECT/CT was performed in 145 patients recruited in 9 nuclear medicine departments. Parenchymal lesions were visible in 126 patients (86.9%). Ground-glass opacities were visible in 33 patients (22.8%) and were responsible for minimal perfusion impairment (perfusion score [mean ± SD], 0.9 ± 0.6) and moderate ventilation impairment (ventilation score, 1.7 ± 1); CP was visible in 43 patients (29.7%) and caused moderate perfusion impairment (2.1 ± 1.1) and moderate-to-severe ventilation impairment (2.5 ± 1.1); consolidation was visible in 89 patients (61.4%) and was associated with moderate perfusion impairment (2.1 ± 1) and severe ventilation impairment (3.0 ± 0.9). Conclusions: In COVID-19 patients assessed with V/Q SPECT/CT, a large proportion demonstrated parenchymal lung lesions on CT, responsible for ventilation and perfusion injury. COVID-19-related pulmonary lesions were, in order of frequency and functional impairment, consolidations, CP, and ground-glass opacity, with typically a reverse mismatched or matched pattern. Competing Interests: Conflicts of interest and sources of funding: none declared. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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