Exercise intervention prevents early aged hypertension-caused cardiac dysfunction through inhibition of cardiac fibrosis.

Autor: Hong Y; The First Rehabilitation Hospital of Shanghai, Shanghai, China., Yang AL; Department of Sports Sciences, University of Taipei, Taipei, Taiwan., Wong JKS; Department of Cardiology, Asia University Hospital, Taichung, Taiwan.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan., Masodsai K; Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand., Lee SD; Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.; Department of Physical Therapy, Asia University, Taichung, Taiwan.; School of Rehabilitation Medicine, Weifang Medical University, Shandong, China., Lin YY; Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: Aging [Aging (Albany NY)] 2022 May 23; Vol. 14 (10), pp. 4390-4401. Date of Electronic Publication: 2022 May 23.
DOI: 10.18632/aging.204077
Abstrakt: Background: An inappropriate accumulation of fibrillar collagen is a common pathologic feature of early aged hypertensive heart disease, but little information regarding the effects of exercise training on cardiac fibrosis in hypertension is available. The purpose of this study was to evaluate the effects of exercise training on cardiac fibrotic pathways in early aged hypertensive rats.
Methods: Masson's trichrome staining and Western blotting were performed on the excised left ventricle from twenty male spontaneously hypertensive rats at age of 48 weeks, which were randomly divided into either a sedentary hypertensive group (SHR) or exercise hypertensive group (SHR-EX, running on a treadmill running occurred 5 days/week for 60 min/day, for 12 weeks), and from age-matched male Wistar-Kyoto normotensive controls (WKY).
Results: Interstitial fibrosis was reduced in the SHR-Ex group when compared with the SHR group. The fibrotic-related protein levels of AT 1 R, FGF23, LOX-2, TGF-β, CTGF, p-Smad 2/3, MMP-2/TIMP-2, MMP-9/TIMP-1, uPA and collagen I were decreased in the SHR-EX group, when compared with the SHR group.
Conclusions: Exercise training suppresses early aged hypertensive heart-induced LOX-2/TGF-β-mediated fibrotic pathways associated with decreasing AT 1 R and FGF23, which might provide a new therapeutic effect for exercise training to prevent adverse cardiac fibrosis and myocardial abnormalities in early aged hypertension.
Databáze: MEDLINE
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