The relationship between using estrogen and/or progesterone and the risk of mammary gland hyperplasia in women: a meta-analysis.

Autor: Yan Z; College of Pharmacy, Dali University, Dali, PR China., Yun-Yun L; Department of Pharmacy, The Second People's Hospital of Quzhou Zhejiang, Quzhou, PR China., Zhou T; College of Pharmacy, Dali University, Dali, PR China., Li-Rong C; College of Pharmacy, Dali University, Dali, PR China., Xiao-Li Y; College of Pharmacy, Dali University, Dali, PR China., Yong L; College of Pharmacy, Dali University, Dali, PR China.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2022 Jul; Vol. 38 (7), pp. 543-547. Date of Electronic Publication: 2022 May 23.
DOI: 10.1080/09513590.2022.2076831
Abstrakt: Background: As reported that the usage of estrogen and/or progesterone increases the risk of mammary gland hyperplasia (MGH) with conflicting results. Therefore, we conducted a meta-analysis to higher elucidate the relationship between hormones and MGH.
Method: PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, and Wan-fang database were searched for studies until April 28, 2021.
Results: Nine related studies were included in the present meta-analysis. We found that the usage of estrogen and/or progesterone had a significant association with increasing the risk of MGH (RR = 1.56, 95% CI: 1.13-2.15, p  = .000). The subgroup results showed that the risk of MGH increased in the Mix population (RR = 1.72, CI: 1.58-1.88, p  < .001) but no significant difference in the Asian population. Meanwhile, as for using estrogen plus progesterone (EPP) and postmenopausal women the risk of MGH, respectively, increased (RR = 1.74, CI: 1.22-2.47, p  = .002) and (RR = 1.75, CI: 1.24-2.47, p  = .001) but no significant different for using estrogen alone and premenopausal women.
Conclusions: This study findings indicated that using estrogen and/or progesterone might increase the risk of MGH in premenopausal and postmenopausal women.
Databáze: MEDLINE
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