| Autor: |
Lama Tamang R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Juritsch AF; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Ahmad R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Salomon JD; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA., Dhawan P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska, USA., Ramer-Tait AE; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Singh AB; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska, USA. |
| Abstrakt: |
The intestinal barrier orchestrates selective permeability to nutrients and metabolites while excluding noxious stimuli. Recent scientific advances establishing a causal role for the gut microbiota in human health outcomes have generated a resurgent interest toward intestinal permeability. Considering the well-established role of the gut barrier in protection against foreign antigens, there is mounting evidence for a causal link between gut permeability and the microbiome in regulating human health. However, an understanding of the dynamic host-microbiota interactions that govern intestinal barrier functions remains poorly defined. Furthermore, the system-level mechanisms by which microbiome-targeted therapies, such as probiotics and prebiotics, simultaneously promote intestinal barrier function and host health remain an area of active investigation. This review summarizes the recent advances in understanding the dynamics of intestinal permeability in human health and its integration with gut microbiota. We further summarize mechanisms by which probiotics/prebiotics influence the gut microbiota and intestinal barrier functions. |
