Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice.

Autor:	Hamed AMR; Department Of Medical Parasitology, Faculty Of Medicine, Cairo University, Cairo Egypt., Abdel-Shafi IR; Department Of Medical Parasitology, Faculty Of Medicine, Cairo University, Cairo Egypt., Elsayed MDA; Anatomy and Embryology Department, Faculty of Medicine, Cairo University, Cairo Egypt., Mahfoz AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.; Egyptian Drug Authority, Cairo, Egypt., Tawfeek SE; Anatomy Department, College of Medicine, Jouf University, Sakaka, Saudi Arabia.; Human Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Zagazig Egypt., Abdeltawab MSA; Department Of Medical Parasitology, Faculty Of Medicine, Cairo University, Cairo Egypt.
Jazyk:	angličtina
Zdroj:	Helminthologia [Helminthologia] 2022 May 04; Vol. 59 (1), pp. 18-36. Date of Electronic Publication: 2022 May 04 (Print Publication: 2022).
DOI:	10.2478/helm-2022-0002
Abstrakt:	Background: Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections. Objective: Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole. Methods: Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 mg/kg and were compared with control infected and non-infected mice. Estimation of intestinal and muscular parasitic load and blood malondialdehyde level, in addition to the histopathological examination of small intestine, skeletal muscle tissue and heart was performed. Also, assessment of the local expression of cyclooxygenase-2 enzyme (COX-2) and CD34 in these samples was done by immunohistochemistry. Results: Curcumin was found efficient in reducing parasitic load. It also lowered serum MDA level, local COX-2 and CD34 expression. An evident anti-inflammatory effect of curcumin was observed in intestinal, skeletal muscle and cardiac muscle histopathological sections. Conclusion: The anti-inflammatory, anti-oxidant and anti-angiogenic effects of curcumin can help to improve trichinellosis-induced pathology. Curcumin can therefore be of value as an adjuvant therapy to conventional antiparasitic agents and can also produce promising results when used alone at higher doses. Competing Interests: Conflict of interest The authors declare that there is no conflict of interest. (© 2022 A. M. R. Hamed, I. R. Abdel-Shafi, M. D. A. Elsayed, A. M. Mahfoz, S. E. Tawfeek, M. S. A. Abdeltawab, published by Sciendo.)
Databáze:	MEDLINE
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