ZnT8 autoantibody prevalence is low in youth with type 2 diabetes and associated with higher insulin sensitivity, lower insulin secretion, and lower disposition index.

Autor:	Higgins J; University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Zeitler P; University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Drews KL; George Washington University Biostatistics Center, Rockville, United States., Arslanian S; UPMC-Children's Hospital of Pittsburgh, Pittsburgh, PA, United States., Copeland K; University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States., Goland R; Columbia University, New York, NY, United States., Klingensmith G; University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Lipman TH; Children's Hospital of Philadelphia, Philadelphia, PA, United States., Tollefsen S; Saint Louis University Health Sciences Center, Saint Louis, MO, United States.
Jazyk:	angličtina
Zdroj:	Journal of clinical & translational endocrinology [J Clin Transl Endocrinol] 2022 May 11; Vol. 29, pp. 100300. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
DOI:	10.1016/j.jcte.2022.100300
Abstrakt:	Aim: ZnT8 autoantibody positivity (ZnT8+) is associated with risk for type 1 diabetes and with metabolic complications in adults. Our aim was to assess prevalence of ZnT8 + in the Treatment of T2D in Adolescents and Youth (TODAY) cohort and describe associated phenotypic outcomes. Methods: TODAY participants were 13.98 ± 2.03 years with a confirmed diagnosis of T2D, BMI percentile of 97.69 ± 3.32 (64% female), and GAD- and IA2- at baseline. ZnT8 autoantibodies were measured at baseline and end of study. Results: 3 of 687 participants (0.29%) were ZnT8 + and there was one conversion (0.15%) from ZnT8- to ZnT8 + during the study. ZnT8A + individuals had higher HbA1c, HDL and LDL cholesterol, and IL-1β concentrations, and lower BMI, IL-6, and triglyceride concentrations compared to the TODAY cohort and ZnT8A- individuals. They also had higher insulin sensitivity with lower insulin secretion and disposition index, metabolically resembling T1D. All ZnT8 + participants experienced loss of glycemic control on randomized treatment, but exhibited lower rates of diabetic complications than other groups. Conclusion: Given the low rate of complications in ZnT8 + individuals, ZnT8 likely does not impact the clinical course of the disease in this population. (© 2022 The Author(s).)
Databáze:	MEDLINE
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