Clinical features, laboratory characteristics and risk factors for mortality of COVID-19 patients in a secondary hospital in Oman during the first wave of the SARS-CoV-2 pandemic.

Autor: Almayahi ZK; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Raveendran AV; Internal Medicine Department, Bader Al Samaa Hospital, Barka, Oman., Al Malki R; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Safwat A; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Al Baloshi M; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Abbas A; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Al Salami AS; Laboratory Department, Rustaq Hospital, Ministry of Health, Rustaq, Oman., Al Mujaini SM; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Al Dhuhli K; Disease Surveillance and Control Department, Ministry of Health, P.O. Box 543, P.C 329 Rustaq, South Batinah Governorate Oman., Al Mandhari S; Anesthesia Department, Rustaq Hospital, Ministry of Health, Rustaq, Oman.
Jazyk: angličtina
Zdroj: Bulletin of the National Research Centre [Bull Natl Res Cent] 2022; Vol. 46 (1), pp. 139. Date of Electronic Publication: 2022 May 16.
DOI: 10.1186/s42269-022-00825-w
Abstrakt: Background: The changing epidemiological profile of the COVID-19 pandemic and the uncertain clinical picture of patients characterise this ongoing and most challenging health event.
Objectives: To report clinical features, laboratory characteristics, and mortality risk factors among COVID-19 patients admitted to a secondary hospital in Oman.
Methods: A retrospective study for the first 455 patients admitted with COVID-19 to Rustaq hospital from 12th April, 2020 to 27th September, 2020. A predesigned questionnaire collected data from the hospital medical electronic system.
Results: The mean age was 42.84 (SD = 19.86) years, and the majority of patients were aged 30 to 59 and 60 or above; 207 (45.5%) and 189 (41.5%), respectively. Male patients constituted approximately two-thirds of the subjects. Fever, dyspnea and cough were the most common presenting symptoms (69%, 66%, and 62%, respectively), while comorbidities with diabetes mellitus and hypertension were 47% and 44%, respectively. Bacterial growth was identified at approximately 10%. Bivariate analysis turned out to be significant with a number of factors. However, multivariate analysis showed significance with patients aged over 60 (OR = 7.15, 95% CI 1.99-25.63), dyspnea (OR = 2.83, 95% CI 1.5-5.33), dyslipidemia (OR = 1.93, 95% CI 1.02-3.66) and being bed-ridden (OR = 5.01, 95% CI 1.73-14.44). Durations from onset of symptoms to admission and respiratory distress were lower among patients who died; p  = 0.024 and p  = 0.001, respectively. Urea, Troponin and LDH may act as potential diagnostic biomarkers for severity or mortality.
Conclusions: This study identified groups of patients with a higher risk of mortality, with severe disturbance in the laboratory markers while some could act as potential diagnostic biomarkers.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s) 2022.)
Databáze: MEDLINE
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