The ERG1 K + Channel and Its Role in Neuronal Health and Disease.
| Autor: | Sanchez-Conde FG; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, United States., Jimenez-Vazquez EN; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, United States., Auerbach DS; Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY, United States., Jones DK; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, United States.; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 May 03; Vol. 15, pp. 890368. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022). |
| DOI: | 10.3389/fnmol.2022.890368 |
| Abstrakt: | The ERG1 potassium channel, encoded by KCNH2 , has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Sanchez-Conde, Jimenez-Vazquez, Auerbach and Jones.) |
| Databáze: | MEDLINE |
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