[Troponin-T and n-terminal pro-brain type natriuretic peptide plasma levels and its relationship with mortality in COVID-19].

Autor: Ghelfi AM; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina. Electronic address: albertinaghelfi@hotmail.com., Sánchez BA; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Berbotto LA; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Dipaolo FR; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Bosque V; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Velez LL; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Cordone MA; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Pallero RN; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Yiguerimian LM; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina., Kilstein JG; Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina.
Jazyk: Spanish; Castilian
Zdroj: Hipertension y riesgo vascular [Hipertens Riesgo Vasc] 2022 Jul-Sep; Vol. 39 (3), pp. 105-113. Date of Electronic Publication: 2022 Apr 28.
DOI: 10.1016/j.hipert.2022.03.002
Abstrakt: Introduction: Cardiovascular compromise in coronavirus disease 2019 (COVID-19) does not necessarily present with the classic symptoms described in myocarditis. There is growing evidence demonstrating subclinical cardiovascular compromise in the context of the intense inflammation unleashed, the cytokine storm involved, the baseline prothrombotic state, and the consequent endothelial dysfunction. We set out to analyse whether Troponin-T (TT) and the amino-terminal fraction of pro-brain natriuretic peptide (NT-proBNP) determined at hospital admission, are related to mortality during the hospitalization of these patients.
Material and Methods: Analytical, observational, retrospective cohort and cross-sectional study. It included subjects with COVID-19 hospitalized for moderate-severe illness, from 20/03/20 to 15/11/20. The TT and NT-proBNP obtained in the first 24 hours from admission were analysed. Altered TT was considered if ≥.014 ng/dl and altered NT-proBNP if ≥300 pg/ml.
Results: One hundred and eight subjects were included, 63.2% men, age 51.5 years (59-43), 28% were admitted to the Critical Unit and 25% died. The group with elevated TT presented higher mortality (OR = 3.1; 95%CI = 1.10-8.85; p = .02). The group with elevated NT-proBNP also show higher mortality (OR = 3.47; 95%CI = 1.21-9.97; p = .01). On multivariate analysis, only NT-proBNP ≥300 pg/ml remained an independent risk factor.
Conclusions: NT-proBNP levels ≥300 pg/ml at admission in patients with moderate-severe COVID-19 were associated with higher mortality.
(Copyright © 2022 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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