Quantifying how drug-polymer interaction and volume phase transition modulate the drug release kinetics from core-shell microgels.

Autor: Lim PT; School of Engineering, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia., Irwan RM; School of Engineering, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia., Li Z; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Republic of Singapore; Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Goh KB; School of Engineering, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia. Electronic address: kekboon.goh@monash.edu.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2022 Jun 25; Vol. 622, pp. 121838. Date of Electronic Publication: 2022 May 18.
DOI: 10.1016/j.ijpharm.2022.121838
Abstrakt: This paper presents a simple experimental-informed theory describing the drug release process from a temperature-responsive core-shell microgel. In stark contrast to the commonly employed power-law models, we couple electric, hydrophobic, and steric factors to characterize the impact of drug-polymer pair interaction on the release kinetics. To this end, we also propose a characteristic time, depicting the drug release process as an interplay between kinetics and thermodynamics. In some instances, the negative correlation between the diffusivity and the (thermodynamics) drug-polymer interaction renders the drug release time non-trivial. In conclusion, our theory establishes a mechanistic understanding of the drug release process, exploring the effect of (hydrophobic adhesion) attractive and (steric exclusion) repulsive pair interactions between the drugs and the microgel in the presence of temperature-induced volume phase transition.
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Databáze: MEDLINE
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