Advances in Hydrogel-Based Drug Delivery Systems for Parkinson's Disease.

Autor: Nguyen TT; Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, 700000, Vietnam., Bao NS; Department of Neurosurgery, School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. bsbao115@gmail.com.; Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. bsbao115@gmail.com., Van Vo G; Department of Biomedical Engineering, School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. vvgiau@medvnu.edu.vn.; Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. vvgiau@medvnu.edu.vn.; Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. vvgiau@medvnu.edu.vn.
Jazyk: angličtina
Zdroj: Neurochemical research [Neurochem Res] 2022 Aug; Vol. 47 (8), pp. 2129-2141. Date of Electronic Publication: 2022 May 20.
DOI: 10.1007/s11064-022-03617-w
Abstrakt: Parkinson's disease (PD) is a common central nervous system disorder (CNS) characterized by cell loss in the substantia nigra. Severe loss of dopaminergic neurons and Lewy body formation with α-synuclein inclusions are the main neuropathological features of PD. There's currently no cure for PD, but treatments are available to help relieve the symptoms and maintain quality of life. However, the variety of clinically available therapeutic molecules is mainly limited to treating symptoms rather than halting or reversing disease progression via medical interventions. As an emerging drug carrier, hydrogels loaded with therapeutic agents and cells are attracting attention as an alternative and potentially more effective approach to managing PD. The current work highlights applications of hydrogel-based biomaterials in cell culture and disease modeling as carriers for cells, medicines, and proteins as PD therapeutic models.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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