Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA and DNA.

Autor:	Lam LKM; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Dobkin J; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Eckart KA; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Gereg I; Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA., DiSalvo A; Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and., Nolder A; Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and., Anis E; Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA., Ellis JC; Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA., Turner G; Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and., Mangalmurti NS; Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; nspatel@pennmedicine.upenn.edu.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Jazyk:	angličtina
Zdroj:	ImmunoHorizons [Immunohorizons] 2022 May 20; Vol. 6 (5), pp. 299-306. Date of Electronic Publication: 2022 May 20.
DOI:	10.4049/immunohorizons.2200013
Abstrakt:	RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid-sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat erythrocytes possess immune function and may be reservoirs for nucleic acids. These findings provide unique insight into bat immunity and may uncover potential mechanisms by which virulent pathogens of humans are concealed in bats. (Copyright © 2022 The Authors.)
Databáze:	MEDLINE
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