Clinical Features of Patients With Second Primary Lung Cancer After Head and Neck Cancer.

Autor:	Takatsu F; Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan; Okayama University Thoracic Surgery Study Group, Okayama, Japan., Suzawa K; Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan; Okayama University Thoracic Surgery Study Group, Okayama, Japan. Electronic address: ksuzawa@okayama-u.ac.jp., Okazaki M; Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan; Okayama University Thoracic Surgery Study Group, Okayama, Japan., Shien K; Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan; Okayama University Thoracic Surgery Study Group, Okayama, Japan., Yamamoto H; Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan; Okayama University Thoracic Surgery Study Group, Okayama, Japan., Watanabe M; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Japan., Hayama M; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Japanese Red Cross Okayama Hospital, Okayama, Japan., Ueno T; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Ehime, Japan., Sugimoto R; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Ehime University Hospital, Ehime, Japan., Maki Y; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan., Fujiwara T; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan., Okita R; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Yamaguchi-Ube Medical Center, Yamaguchi, Japan., Inokawa H; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Yamaguchi-Ube Medical Center, Yamaguchi, Japan., Tao H; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Japanese Red Cross Society Himeji Hospital, Hyogo, Japan., Hirami Y; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Okayama Medical Center, Okayama, Japan., Matsuda E; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Saiseikai Imabari Hospital, Ehime, Japan., Kataoka K; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Japan., Yamashita M; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Ehime, Japan., Sano Y; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Ehime University Hospital, Ehime, Japan., Matsuura M; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan., Mizutani H; Okayama University Thoracic Surgery Study Group, Okayama, Japan; Department of Thoracic Surgery, Japanese Red Cross Society Himeji Hospital, Hyogo, Japan., Toyooka S; Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan; Okayama University Thoracic Surgery Study Group, Okayama, Japan.
Jazyk:	angličtina
Zdroj:	The Annals of thoracic surgery [Ann Thorac Surg] 2024 Jan; Vol. 117 (1), pp. 181-188. Date of Electronic Publication: 2022 May 17.
DOI:	10.1016/j.athoracsur.2022.04.052
Abstrakt:	Background: In survivors of head and neck cancer (HNC), second primary lung cancer (SPLC) often develop as a result of a common risk factor, that is, smoking. A multicenter experience was reviewed to evaluate how the history of a diagnosis of HNC affects the outcomes of patients undergoing pulmonary resection for SPLC. Methods: A multicenter retrospective analysis of patients hospitalized between January 2012 and December 2018 was performed. From a cohort of 4521 patients undergoing therapeutic pulmonary resection for primary non-small cell lung cancer, 100 patients with a previous history of HNC (HNC group) were identified. These patients were compared with a control group consisting of 200 patients without an HNC history from the same cohort pair-matched with operating facility, age, sex, and pathologic stage of lung cancer. Results: At the time of surgery for SPLC, the HNC group showed malnutrition with a lower prognostic nutritional index compared with the control group (P < .001). The HNC group was determined to have postoperative complications more frequently (P = .02). The 5-year overall survival rates in the HNC and control groups were 59.0% and 83.2%, respectively (P < .001). Statistically, HNC history, lower prognostic nutritional index, squamous cell lung cancer, and TNM stage were identified to be independently associated with poor survival. Conclusions: Patients with SPLC after primary HNC often present with malnutrition and are predisposed to postoperative complications and poor survival after pulmonary resection. (Copyright © 2024 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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