Naturally occurring dimeric triterpenoids: Occurrence, chemistry and bioactivities.

Autor: Happi GM; Department of Chemistry, Higher Teacher Training College, The University of Bamenda, P.O Box 39, Bambili, Cameroon. Electronic address: gervais20022003@yahoo.fr., Ntabo VK; Department of Chemistry, Higher Teacher Training College, The University of Bamenda, P.O Box 39, Bambili, Cameroon., Tcho AT; Department of Chemistry, Faculty of Sciences, University of Buea, P.O. Box 63, Buea, Cameroon., Wansi JD; Department of Chemistry, Faculty of Sciences, University of Douala, P. O. Box 24157, Douala, Cameroon.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2022 Aug; Vol. 200, pp. 113242. Date of Electronic Publication: 2022 May 17.
DOI: 10.1016/j.phytochem.2022.113242
Abstrakt: The triterpenes represent one of the most reported subclasses of specialized metabolites from the plant kingdom. They play a key role in the protection of plants and their metabolism in addition to displaying a high structural diversity and large scale of biological activities. The scaffold can undergo several reactions like oxidation or substitution at different positions of the skeleton leading to the formation of several types of compounds. More specifically, triterpene dimer is a small group of compounds found in nature (from plants precisely). Until 2021, the chemical and pharmacological works reported in the literature indicated the identification of 90 natural dimeric triterpenes and 11 synthetic derivatives from 19 plants species and very few of them have been biologically evaluated for their antibacterial, antioxidant, antiproliferative or molluscicide activities. This review aims to compile the literature on the occurrence, chemistry and biological activities of the triterpenoid dimers. To attend this goal, a literature survey has been done in a number of online libraries including Scifinder, PubMed, Web of Science and Google Scholar using keywords terpene, triterpene, dimer, celastroloid without language restriction. This paper provides the easiest access to the information on triterpene dimers for readers and researchers in view to enhancing the continuity of research works on this topic.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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