Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson's disease: a pilot and feasibility study.

Autor:	Donahue EK; Department of Neurology, University of Southern California.; Neuroscience Graduate Program, University of Southern California, Los Angeles, California., Bui V; Department of Neurology, University of Southern California., Foreman RP; Department of Neurology, University of Southern California., Duran JJ; Department of Neurology, University of Southern California., Venkadesh S; Department of Psychology, University of Virginia, Charlottesville, Virginia., Choupan J; Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California., Van Horn JD; Department of Psychology, University of Virginia, Charlottesville, Virginia.; School of Data Science, University of Virginia, Charlottesville, Virginia., Alger JR; Department of Neurology, University of California, Los Angeles., Jakowec MW; Department of Neurology, University of Southern California., Petzinger GM; Department of Neurology, University of Southern California., O'Neill J; Division of Child Psychiatry, UCLA Semel Institute for Neuroscience, Los Angeles, California, USA.
Jazyk:	angličtina
Zdroj:	Neuroreport [Neuroreport] 2022 May 04; Vol. 33 (7), pp. 291-296. Date of Electronic Publication: 2022 Apr 08.
DOI:	10.1097/WNR.0000000000001781
Abstrakt:	Objective: Higher volume fraction of perivascular space (PVS) has recently been reported in Parkinson's disease (PD) and related disorders. Both elevated PVS and altered levels of neurometabolites, assayed by proton magnetic resonance spectroscopy (MRS), are suspected indicators of neuroinflammation, but no published reports have concurrently examined PVS and MRS neurometabolites. Methods: In an exploratory pilot study, we acquired multivoxel 3-T MRS using a semi-Localization by Adiabatic SElective Refocusing (sLASER) pulse-sequence (repetition time/echo time = 2810/60 ms, voxels 10 × 10 × 10 mm3) from a 2D slab sampling bilateral frontal white matter (FWM) and anterior middle cingulate cortex (aMCC). PVS maps obtained from high-resolution (0.8 × 0.8 × 0.8 mm3) T1-weighted MRI were co-registered with MRS. In each MRS voxel, PVS volume and neurometabolite levels were measured. Results: Linear regression accounting for age, sex, and BMI found greater PVS volume for higher levels of choline-containing compounds (Cho; P = 0.047) in FWM and lower PVS volume for higher levels of N-acetyl compounds (NAA; P = 0.012) in aMCC. Since (putatively) higher Cho is associated with inflammation while NAA has anti-inflammatory properties, these observations add to evidence that higher PVS load is a sign of inflammation. Additionally, lower Montreal Cognitive Assessment scores were associated with lower NAA in aMCC (P = 0.002), suggesting that local neuronal dysfunction and inflammation contribute to cognitive impairment in PD. Conclusion: These exploratory findings indicate that co-analysis of PVS and MRS is feasible and may help elucidate the cellular and metabolic substrates of glymphatic and inflammatory processes in PD. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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