Homologous or heterogenous vaccination boosters enhance neutralizing activities against SARS-CoV-2 Omicron BA.1 variant.

Autor: Zhou Z; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Du P; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China.; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China.; Department of Bioinformatics and AI Guangzhou Laboratory Guangzhou P. R. China., Li N; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Xiong X; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Tang S; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Dai Q; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Wang T; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China.; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China.; Department of Bioinformatics and AI Guangzhou Laboratory Guangzhou P. R. China., Yu M; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Man M; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Lam K; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China., Baptista-Hon DT; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China., Tai WH; St. Januario Central Hospital Macau P. R. China., Monteiro O; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China., Ng WS; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China., Lee UM; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China., Liu Z; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China., Zhang K; University Hospital and Center for Biomedicine and Innovations, Faculty of Medicine Macau University of Science and Technology Macau P. R. China.; Department of Bioinformatics and AI Guangzhou Laboratory Guangzhou P. R. China., Li G; Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou P. R. China.; Department of Bioinformatics and AI Guangzhou Laboratory Guangzhou P. R. China.
Jazyk: angličtina
Zdroj: MedComm [MedComm (2020)] 2022 May 11; Vol. 3 (2), pp. e143. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
DOI: 10.1002/mco2.143
Abstrakt: The SARS-CoV-2 Omicron BA.1 variant of concern contains more than 30 mutations in the spike protein, with half of these mutations localized in the receptor-binding domain (RBD). Emerging evidence suggests that these large number of mutations impact the neutralizing efficacy of vaccines and monoclonal antibodies. We investigated the relative contributions of spike protein and RBD mutations in Omicron BA.1 variants on infectivity, cell-cell fusion, and their sensitivity to neutralization by monoclonal antibodies or vaccinated sera from individuals who received homologous (CoronaVac, SinoPharm) or heterologous (CoronaVac-BNT162b2, BioNTech) and nonhuman primates that received a recombinant RBD protein vaccine. Our data overall reveal that the mutations in the spike protein reduced infectivity and cell-cell fusion compared to the D614G variant. The impaired infectivity and cell-cell fusion were dependent on non-RBD mutations. We also find reduced sensitivity to neutralization by monoclonal antibodies and vaccinated sera. However, our results also show that nonhuman primates receiving a recombinant RBD protein vaccine show substantial neutralization activity. Our study sheds light on the molecular differences in neutralizing antibody escape by the Omicron BA.1 variant, and highlights the promise of recombinant RBD vaccines in neutralizing the threat posed by the Omicron BA.1 variant.
Competing Interests: Kang Zhang is an editorial board member of MedComm. Author Kang Zhang was not involved in the journal's review of, or decisions related to, this manuscript. The other authors declared no conflict of interest.
(© 2022 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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