Biosafety evaluation of two Beauveria bassiana products on female albino rats using acute oral test.

Autor:	Sayed Ali S; Bio-Insecticide Production Unit, Plant Protection Research Institute, Agricultural Research Center, Giza, Egypt., El-Saadany HM; Bio-Insecticide Production Unit, Plant Protection Research Institute, Agricultural Research Center, Giza, Egypt., Kotb GAM; Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza 12618, Egypt., Elshaer N; Department of Plant Protection, Faculty of Agriculture, Zagazig University, 44511 Zagazig, Egypt., Melebary SJ; Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia., Soliman SM; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt., A Gh Farag A; Department of Plant Protection, Faculty of Agriculture, Zagazig University, 44511 Zagazig, Egypt.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2022 Jun; Vol. 29 (6), pp. 103293. Date of Electronic Publication: 2022 Apr 21.
DOI:	10.1016/j.sjbs.2022.103293
Abstrakt:	Application of bio-pesticides in agriculture has been developed as alternative agents to conventional pesticides due to residues accumulating which causing detrimental effects to human and environment. The aim of this investigation is to evaluate biosafety of a bio-insecticide Beauveria bassiana using two products in female rats by single oral dose through hepato- and renal toxicity, hematotoxicity and lipid profile. The two products from B. bassiana (AUMC 9896) were metabolic crude (MC), and wettable powder formulation (WP) of the local isolate. Results showed a significant increase in values of erythrocytes (RBCs), leucocytes (WBCs), platelet count (Plt) and the absolute differential WBC counts. Liver enzymes (AST, ALT, and ALP) and globulin (Glb) content were reduced in the exposed female rats with both types of B. bassiana in comparison to controls. While ratio of AST/ALT and A/G, total protein level (TP) and albumin (Alb) were raised in Beauveria bassiana -treated rats ( Bb - treated rats) . Urea and creatinine concentrations decreased or increased significantly in treated rats. Moreover, there was a decline in the serum of lipid profiles in WP - treated rats, but LDL levels increased in all treated animal. Additionally, no mortality or toxicity in all treated. All animals treated showed non-significant modifications in body weight gain and a slight change in relative liver weights when compared to controls. These results suggest that both treatments effect markedly on function and somatic index of the liver and slight effects on CBC and lipid profile aspects of treated female rats. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Author(s).)
Databáze:	MEDLINE
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