Prevalence of Blood-Borne Viruses and Predictors of Risk in Potential Organ Donors in Australia.

Autor:	Dutch MJ; Royal Melbourne Hospital, Melbourne, VIC, Australia.; DonateLife (Victoria), Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia., Patrick CJ; Statistical Consultancy Unit, University of Melbourne, Melbourne, VIC, Australia., Boan PA; Microbiology Department, PathWest Laboratory Medicine, Perth, WA, Australia.; Department of Infectious Disease, Fiona Stanley Hospital, Perth, WA, Australia., Knott JC; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.; Emergency Department, Royal Melbourne Hospital, Melbourne, VIC, Australia., Opdam HI; Intensive Care Unit, Austin Hospital, Melbourne, VIC, Australia.; Australian Organ and Tissue Authority, Canberra, ACT, Australia.
Jazyk:	angličtina
Zdroj:	Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2022 May 03; Vol. 35, pp. 10395. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
DOI:	10.3389/ti.2022.10395
Abstrakt:	Internationally, the designation of a patient as an increased viral risk organ donor has been associated with lower utilisation rates. The actual prevalence of blood borne viruses in Australian potential organ donors, and the predictive performance of questionnaires administered to stratify this risk, remains unknown. We conducted a retrospective review of all patients who commenced workup for donation on the national database between 2014-2020. The prevalence of HIV, Active HBV and Active HCV in 3650 potential organ donors was 0.16%, 0.9%, and 2.2%, respectively. The behavioural risk profile was assessed in a subset of 3633 patients. Next-of-kin reported increased risk behaviours were associated with an increased prevalence of HCV but not of HIV or HBV (OR 13.8, p < 0.01, OR 0.3. p = 0.42, OR 1.5, p = 0.14). Furthermore, the majority of HIV and HBV infections occurred in potential donors without a disclosed history of increased risk behaviours. In this series, donors had a higher prevalence of HCV, and similar rates of HBV and HIV to the broader community. Behavioural transmission risks were poorly predictive of HIV and HBV. Rather than pre-transplantation behavioural risk screening, routine post-transplant recipient screening may provide a more powerful tool in mitigating the consequences of unexpected viral transmission. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Dutch, Patrick, Boan, Knott and Opdam.)
Databáze:	MEDLINE
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