Bioceramics Based on β-Calcium Pyrophosphate.

Autor: Safronova T; Department of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, Russia.; Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia., Kiselev A; Department of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, Russia., Selezneva I; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya, 3, 142290 Pushchino, Russia., Shatalova T; Department of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, Russia.; Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia., Lukina Y; Priorov National Medical Research Center of Traumatology and Orthopedics, Priorova, 10, 127299 Moscow, Russia.; Department of Engineering Design of Technological Equipment, Mendeleev University of Chemical Technology, Miusskaya, 9, 125047 Moscow, Russia., Filippov Y; Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia.; Research Institute of Mechanics, Lomonosov Moscow State University, Michurinsky, 1, 119192 Moscow, Russia., Toshev O; Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia., Tikhonova S; Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia., Antonova O; Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russia., Knotko A; Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2022 Apr 25; Vol. 15 (9). Date of Electronic Publication: 2022 Apr 25.
DOI: 10.3390/ma15093105
Abstrakt: Ceramic samples based on β-calcium pyrophosphate β-Ca 2 P 2 O 7 were prepared from powders of γ-calcium pyrophosphate γ-Ca 2 P 2 O 7 with preset molar ratios Ca/P = 1, 0.975 and 0.95 using firing at 900, 1000, and 1100 °C. Calcium lactate pentahydrate Ca(C 3 H 5 O 3 ) 2 ⋅5H 2 O and monocalcium phosphate monohydrate Ca(H 2 PO 4 ) 2 ⋅H 2 O were treated in an aqua medium in mechanical activation conditions to prepare powder mixtures with preset molar ratios Ca/P containing calcium hydrophosphates with Ca/P = 1 (precursors of calcium pyrophosphate Ca 2 P 2 O 7 ). These powder mixtures containing calcium hydrophosphates with Ca/P = 1 and non-reacted starting salts were heat-treated at 600 °C after drying and disaggregation in acetone. Phase composition of all powder mixtures after heat treatment at 600 °C was presented by γ-calcium pyrophosphate γ-Ca 2 P 2 O 7 according to the XRD data. The addition of more excess of monocalcium phosphate monohydrate Ca(H 2 PO 4 ) 2 ·H 2 O (with appropriate molar ratio of Ca/P = 1) to the mixture of starting components resulted in lower dimensions of γ-calcium pyrophosphate (γ-Ca 2 P 2 O 7 ) individual particles. The grain size of ceramics increased both with the growth in firing temperature and with decreasing molar ratio Ca/P of powder mixtures. Calcium polyphosphate (t melt = 984 °C), formed from monocalcium phosphate monohydrate Ca(H 2 PO 4 ) 2 ⋅H 2 O, acted similar to a liquid phase sintering additive. It was confirmed by tests in vitro that prepared ceramic materials with preset molar ratios Ca/P = 1, 0.975, and 0.95 and phase composition presented by β-calcium pyrophosphate β-Ca 2 P 2 O 7 were biocompatible and could maintain bone cells proliferation.
Databáze: MEDLINE
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