| Autor: |
Dohr D; Department of Otorhinolaryngology, Head and Neck Surgery 'Otto Körner', Rostock University Medical Center, 18057 Rostock, Germany., Wulf K; Institute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, Germany., Grabow N; Institute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, Germany., Mlynski R; Department of Otorhinolaryngology, Head and Neck Surgery 'Otto Körner', Rostock University Medical Center, 18057 Rostock, Germany., Schraven SP; Department of Otorhinolaryngology, Head and Neck Surgery 'Otto Körner', Rostock University Medical Center, 18057 Rostock, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Materials (Basel, Switzerland) [Materials (Basel)] 2022 Apr 22; Vol. 15 (9). Date of Electronic Publication: 2022 Apr 22. |
| DOI: |
10.3390/ma15093049 |
| Abstrakt: |
To prevent endocochlear insertion trauma, the development of drug delivery coatings in the field of CI electrodes has become an increasing focus of research. However, so far, the effect of a polymer coating of PLLA on the mechanical properties, such as the insertion pressure and friction of an electrode array, has not been investigated. In this study, the insertion pressure of a PLLA-coated, 31.5-mm long standard electrode array was examined during placement in a linear cochlear model. Additionally, the friction coefficients between a PLLA-coated electrode array and a tissue simulating the endocochlear lining were acquired. All data were obtained at different insertion speeds (0.1, 0.5, 1.0, 1.5, and 2.0 mm/s) and compared with those of an uncoated electrode array. It was shown that both the maximum insertion pressure generated in the linear model and the friction coefficient of the PLLA-coated electrode did not depend on the insertion speed. At higher insertion speeds above 1.0 mm/s, the insertion pressure (1.268 ± 0.032 mmHg) and the friction coefficient (0.40 ± 0.15) of the coated electrode array were similar to those of an uncoated array (1.252 ± 0.034 mmHg and 0.36 ± 0.15). The present study reveals that a PLLA coating on cochlear electrode arrays has a negligible effect on the electrode array insertion pressure and the friction when higher insertion speeds are used compared with an uncoated electrode array. Therefore, PLLA is a suitable material to be used as a coating for CI electrode arrays and can be considered for a potential drug delivery system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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