Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats.

Autor: Woodling KA; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Chitranshi P; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Jacob CC; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Loukotková L; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Von Tungeln LS; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Olson GR; Toxicologic Pathology Associates, Jefferson, AR, USA., Patton RE; Toxicologic Pathology Associates, Jefferson, AR, USA., Francke S; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA., Mog SR; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA., Felton RP; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Beland FA; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA., Zang Y; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA., Gamboa da Costa G; US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA. Electronic address: goncalo.gamboa@fda.hhs.gov.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Jul; Vol. 165, pp. 113137. Date of Electronic Publication: 2022 May 16.
DOI: 10.1016/j.fct.2022.113137
Abstrakt: Brominated vegetable oil (BVO) has been approved by the US Food and Drug Administration on an interim basis as a food additive. Past studies have raised concerns about potential toxicities from consuming BVO. To investigate further these toxicities, we conducted a 90-day dietary exposure study in Sprague Dawley rats and analyzed tissue distribution of the main metabolites. Six-week-old male and female rats were fed diets containing 0 (control), 0.002%, 0.02%, 0.1%, or 0.5% BVO by weight. Statistically significant increases were observed in the serum bromide in the high-dose group of both sexes and in the incidence of thyroid follicular cell hypertrophy in the two highest dose groups of males and the high-dose group of females. An increase in serum TSH was observed in the high-dose group for both sexes, as well as a decrease in serum T4 in the high-dose males. A clear dose-response was observed in di- and tetra-bromostearic acid levels in the heart, liver, and inguinal fat. These data expand upon previous observations in rats and pigs that oral exposure to BVO is associated with increased tissue levels of inorganic and organic bromine, and that the thyroid is a potential target organ of toxicity.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: