Longitudinal measures of phthalate exposure and asthma exacerbation in a rural agricultural cohort of Latino children in Yakima Valley, Washington.

Autor: Babadi RS; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA. Electronic address: rbabadi@uw.edu., Riederer AM; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA., Sampson PD; Department of Statistics, University of Washington, Seattle, WA, 98195, USA., Sathyanarayana S; Seattle Children's Research Institute, Seattle, WA, 98145, USA; Department of Pediatrics, University of Washington, Seattle, WA, 98195, USA., Kavanagh TJ; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA., Krenz JE; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA., Andra SS; Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kim-Schulze S; Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Jansen KL; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA., Torres E; Northwest Communities Education Center, Radio KDNA, Granger, WA, 98932, USA., Perez A; Yakima Valley Farm Workers Clinic, Toppenish, WA, 98901, USA., Younglove LR; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA., Tchong-French MI; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA., Karr CJ; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA, 98195, USA.
Jazyk: angličtina
Zdroj: International journal of hygiene and environmental health [Int J Hyg Environ Health] 2022 Jun; Vol. 243, pp. 113954. Date of Electronic Publication: 2022 May 16.
DOI: 10.1016/j.ijheh.2022.113954
Abstrakt: Phthalates are a class of widely used synthetic chemicals found in commonly used materials and products. Epidemiological studies suggest phthalate exposure is associated with asthma outcomes, though most studies have not investigated phthalates as triggers of exacerbations in children diagnosed with asthma. This study used data from the Home Air in Agriculture Pediatric Intervention Trial (HAPI) to examine relationships between phthalate exposure and outcomes related to childhood asthma exacerbation. We used measures of phthalate metabolites and respiratory health measures including fractional exhaled nitric oxide (FENO), the Asthma Control Test (ACT), caregiver report of symptoms, and urinary leukotriene E 4 (uLTE 4 ) to estimate longitudinal associations using mixed effects models, adjusted for covariates. For 100% (i.e., doubling) increases in mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-2-ethylhexyl phthalate (MEHP), and mono-ethyl phthalate (MEP), concentrations of FENO increased by 8.7% (95% CI: 0.7-17.3), 7.2% (95% CI: 0.0-14.9), and 6.4% (95% CI: 0.0-13.3), respectively. All phthalate metabolites demonstrated associations with uLTE 4 , effect sizes ranging from an 8.7% increase in uLTE 4 (95% CI: 4.3-12.5) for a 100% increase in MEHP to an 18.1% increase in uLTE 4 (95% CI: 13.3-23.1) for a 100% increase in MNBP. In models of caregiver report of symptoms, no phthalate metabolites were significantly associated in primary models. No phthalate metabolites were associated with standardized ACT score. Our results suggest urinary phthalate metabolites are significant predictors of inflammatory biomarkers related to asthma exacerbation in children but not child and caregiver report of airway symptomatology.
(Copyright © 2022. Published by Elsevier GmbH.)
Databáze: MEDLINE
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