| Autor: |
Bonis BM; Department of Microbiology & Immunology, University of Minnesota Medical School, 689 23rd Ave. SE, Minneapolis, MN 55455, USA., Hunter RC; Department of Microbiology & Immunology, University of Minnesota Medical School, 689 23rd Ave. SE, Minneapolis, MN 55455, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medical microbiology [J Med Microbiol] 2022 May; Vol. 71 (5). |
| DOI: |
10.1099/jmm.0.001505 |
| Abstrakt: |
Achromobacter xylosoxidans is associated with resilient nosocomial infections, with bacteraemia, pneumonia and chronic cystic fibrosis lung infection being the most common clinical presentations. Innate multi-drug resistance and a suite of virulence factors select for A. xylosoxidans infection during long-term antibiotic therapy, contributing to its persistence, treatment recalcitrance, association with poor clinical outcomes and emergence as a problematic pathogen. Horizontal gene transfer and maintenance of large genomes underpin the resilience and cosmopolitan lifestyle of A. xylosoxidans , and complicate its phylogenetic characterization. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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