Prosaccade and Antisaccade Behavior in Fragile X-Associated Tremor/Ataxia Syndrome Progression.

Autor: McLennan YA; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Pediatrics University of California Davis Medical Center Sacramento California USA., Mosconi MW; Life Span Institute, Kansas Center for Autism Research and Training, and Clinical Child Psychology Program University of Kansas Lawrence Kansas USA., McKenzie FJ; University of California Davis School of Medicine Sacramento California USA., Famula J; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Psychiatry and Behavioral Sciences University of California Davis Medical Center Sacramento California USA., Krawchuk B; University of California Davis School of Medicine Sacramento California USA., Kim K; Department of Psychology University of California Davis California USA., Clark CJ; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Pediatrics University of California Davis Medical Center Sacramento California USA., Hessl D; The MIND Institute University of California Davis Medical Center Sacramento California USA.; University of California Davis School of Medicine Sacramento California USA., Rivera SM; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Psychology University of California Davis California USA., Simon TJ; The MIND Institute University of California Davis Medical Center Sacramento California USA.; University of California Davis School of Medicine Sacramento California USA., Tassone F; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Biochemistry and Molecular Medicine University of California Davis School of Medicine Sacramento California USA., Hagerman RJ; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Pediatrics University of California Davis Medical Center Sacramento California USA.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2022 Apr 28; Vol. 9 (4), pp. 473-478. Date of Electronic Publication: 2022 Apr 28 (Print Publication: 2022).
DOI: 10.1002/mdc3.13449
Abstrakt: Background: Quantitative measurement of eye movements can reveal subtle progression in neurodegenerative diseases.
Objective: To determine if quantitative measurements of eye movements may reveal subtle progression of fragile X-associated tremor and ataxia (FXTAS).
Methods: Prosaccade (PS) and antisaccade (AS) behavior was analyzed in 25 controls, 57 non-FXTAS carriers, and 46 carriers with FXTAS.
Results: Symptomatic individuals with FXTAS had longer AS latencies, increased rates of AS errors, and increased AS dysmetria relative to non-FXTAS carriers and controls. These deficits, along with PS latency and velocity, were greater in advanced FXTAS stages.
Conclusion: AS deficits differentiated FXTAS from non-FXTAS premutation carriers implicating top-down control and frontostriatal deterioration. However, the absence of group differences between non-FXTAS carriers and controls in AS and PS markers suggests saccade performance may not be a sensitive enough measure for detecting conversion to FXTAS, but instead more helpful as translational biomarkers of FXTAS progression.
(© 2022 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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