Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in adolescent rats.

Autor:	Jadhav KS; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, CH-1008 Lausanne, Switzerland., Bernheim AP; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, CH-1008 Lausanne, Switzerland., Aeschlimann L; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, CH-1008 Lausanne, Switzerland., Kirschmann G; Pain Center, Department of Anesthesiology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine (FBM), University of Lausanne, CH-1011 Lausanne, Switzerland., Decosterd I; Pain Center, Department of Anesthesiology, Lausanne University Hospital (CHUV) and Faculty of Biology and Medicine (FBM), University of Lausanne, CH-1011 Lausanne, Switzerland., Hoffman AF; Electrophysiology Research Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224., Lupica CR; Electrophysiology Research Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224., Boutrel B; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, CH-1008 Lausanne, Switzerland.; Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, CH-1004 Lausanne, Switzerland.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 24; Vol. 119 (21), pp. e2121247119. Date of Electronic Publication: 2022 May 18.
DOI:	10.1073/pnas.2121247119
Abstrakt:	Development of self-regulatory competencies during adolescence is partially dependent on normative brain maturation. Here, we report that adolescent rats as compared to adults exhibit impulsive and compulsive-like behavioral traits, the latter being associated with lower expression of mRNA levels of the immediate early gene zif268 in the anterior insula cortex (AIC). This suggests that underdeveloped AIC function in adolescent rats could contribute to an immature pattern of interoceptive cue integration in decision making and a compulsive phenotype. In support of this, we report that layer 5 pyramidal neurons in the adolescent rat AIC are hypoexcitable and receive fewer glutamatergic synaptic inputs compared to adults. Chemogenetic activation of the AIC attenuated compulsive traits in adolescent rats supporting the idea that in early stages of AIC maturity there exists a suboptimal integration of sensory and cognitive information that contributes to inflexible behaviors in specific conditions of reward availability.
Databáze:	MEDLINE
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